Successful treatment of Trypanoxyuris sp. infection in naturally infected southern brown-howlers (Alouatta guariba clamitans)

IF 2 3区医学 Q3 ECOLOGY International Journal for Parasitology-Parasites and Wildlife Pub Date : 2024-06-15 DOI:10.1016/j.ijppaw.2024.100956

Felipe Rieth de Lima , Luísa Barreto Rippel , Sandy Gabrielly Radünz Machado , Aury Nunes de Moraes , Bárbara Corbellini Rovaris , Anderson Barbosa de Moura , Andreas Lazaros Chryssafidis

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Abstract

Southern brown-howler monkeys (Alouatta guariba clamitans) may harbor Trypanoxyuris sp., a pinworm parasite with documented fatal consequences in this species. Despite this risk, effective treatment protocols remain unclear. Therefore, the present study aimed to evaluate the efficacy of two anthelmintic protocols against natural infections in two brown-howler monkeys received at the Wild Animal Care and Rehabilitation Sector (SARAS-CAV-UDESC). The protocols utilized pyrantel pamoate & praziquantel (600.0 mg, PO, single dose) and albendazole (20.0 mg, PO, daily for 5 days). Fecal egg counts were carried out daily at the Laboratory of Parasitology and Parasitic Diseases (LAPAR-CAV-UDESC) before and after drug administration. Both treatments successfully eliminated Trypanoxyuris sp. infections. The animal treated with pyrantel pamoate & praziquantel achieved egg clearance by day 6 (144 h), demonstrating effectiveness with a single administration. Albendazole cleared the infection within 2 days of treatment, indicating its potential as a fast-acting treatment. No adverse effect were observed in the treated monkeys. These findings contribute to the development of evidence-based treatment protocols for Trypanoxyuris sp. in primates, enhancing animal health and welfare of captive and wild populations.

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成功治疗自然感染南方褐鸮（Alouatta guariba clamitans）的 Trypanoxyuris sp.

南方褐吼猴（Alouatta guariba clamitans）可能携带一种蛲虫寄生虫 Trypanoxyuris sp.尽管存在这种风险，但有效的治疗方案仍不明确。因此，本研究旨在评估野生动物护理和康复中心（SARAS-CAV-UDESC）接收的两只棕尾猴体内两种抗蠕虫药物对自然感染的疗效。这两种方案分别使用了吡噻菌胺&；吡喹酮（600.0 毫克，口服，单剂量）和阿苯达唑（20.0 毫克，口服，每天一次，连续 5 天）。在用药前后，寄生虫学与寄生虫病实验室（LAPAR-CAV-UDESC）每天都会进行粪便虫卵计数。两种治疗方法都成功地消除了 Trypanoxyuris sp.使用帕莫酸噻嘧啶和amp；吡喹酮治疗的动物在第 6 天（144 小时）就能清除虫卵，这表明单次用药就能达到效果。阿苯达唑可在治疗后 2 天内清除感染，这表明它具有速效治疗的潜力。接受治疗的猴子没有出现任何不良反应。这些发现有助于制定灵长类动物Trypanoxyuris sp.的循证治疗方案，提高圈养和野生动物的动物健康和福利。

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来源期刊

International Journal for Parasitology-Parasites and Wildlife Medicine-Infectious Diseases

CiteScore

3.80

自引率

5.60%

发文量

113

审稿时长

45 days

期刊介绍： The International Journal for Parasitology: Parasites and Wildlife (IJP-PAW) publishes the results of original research on parasites of all wildlife, invertebrate and vertebrate. This includes free-ranging, wild populations, as well as captive wildlife, semi-domesticated species (e.g. reindeer) and farmed populations of recently domesticated or wild-captured species (e.g. cultured fishes). Articles on all aspects of wildlife parasitology are welcomed including taxonomy, biodiversity and distribution, ecology and epidemiology, population biology and host-parasite relationships. The impact of parasites on the health and conservation of wildlife is seen as an important area covered by the journal especially the potential role of environmental factors, for example climate. Also important to the journal is ''one health'' and the nature of interactions between wildlife, people and domestic animals, including disease emergence and zoonoses.