Osimertinib efficacious as maintenance therapy in patients with stage III NSCLC

IF 81.1 1区 医学 Q1 ONCOLOGY Nature Reviews Clinical Oncology Pub Date : 2024-06-17 DOI:10.1038/s41571-024-00915-w
Peter Sidaway
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奥希替尼作为III期NSCLC患者的维持疗法疗效显著
被诊断为不可切除的 III 期非小细胞肺癌(NSCLC)患者通常会同时接受化放疗(CRT),然后使用抗 PD-L1 抗体 durvalumab 进行巩固治疗。然而,多项研究数据表明,驱动基因突变阳性肿瘤患者从这种方法中获得的益处往往有限。现在,来自III期LAURA试验的数据证明了osimertinib在III期EGFR突变NSCLC患者CRT后的疗效。共有216名患者在完成标准护理CRT后未出现疾病进展,他们被随机分配(2:1)接受osimertinib或安慰剂治疗。符合条件的患者必须至少有一个表皮生长因子受体外显子19缺失或外显子21中的L858R。无进展生存期(PFS)是主要终点。
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来源期刊
CiteScore
99.40
自引率
0.40%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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