Synthesis of New bis-Heterocyclic Hybrids linked by iso-propanol unit via Hantzsch, Michael, and Biginelli reactions

Abstract

Combining compounds with complementary bioactivities to create hybrid molecules is a new idea in drug research. In this work, we created novel hybrid molecules including bis-heterocycles connected by an isopropanol unit. This is accomplished by the condensation of 4,4'-((2-hydroxypropane-1,3-diyl)bis(oxy))dibenzaldehyde with the appropriate reagents using Hantzsch, Michael, and Biginelli reactions. The structures of the newly synthesized compounds are determined by elemental analysis, 1 H NMR, 13 C NMR, IR, and MS spectra.