{"title":"Horner–Wadsworth–Emmons olefination for bioconjugation","authors":"Yimon Aye","doi":"10.1038/s44160-024-00571-z","DOIUrl":null,"url":null,"abstract":"Through site-specific generation of intermediary reactive aldehydes, Horner–Wadsworth–Emmons olefination can now deliver selective functionalization of stable recombinant proteins and monoclonal antibodies, whilst preserving protein integrity.","PeriodicalId":74251,"journal":{"name":"Nature synthesis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature synthesis","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44160-024-00571-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"0","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Through site-specific generation of intermediary reactive aldehydes, Horner–Wadsworth–Emmons olefination can now deliver selective functionalization of stable recombinant proteins and monoclonal antibodies, whilst preserving protein integrity.
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