Grover's disease: modern ideas about transient and persistent acantholytic dermatosis.

Abstract

Grover's disease is a papulo-vesicular pruritic dermatosis characterized by a transient, persistent, or asymptomatic course. We have analyzed the publications found in the PubMed and RSCI scientific literature databases between 1970 and 2022. The clinical manifestations of Grover's disease, possible localization, etiological factors, and the histological and dermatoscopic picture of the disease are described. According to the literature, the putative associations with disease onset are highly variable and include insolation, pregnancy, hemodialysis, chemotherapy, sweating, a number of dermatoses, and a history of malignancy and organ transplantation. Seasonality of the process has also been described. To date, 9 histologic patterns of the disease have been described, the most common being acantholytic dyskeratosis. In this review, we have included our observations of patients with Grover's disease.