Sphingolipid Signaling and Complement Activation in Glioblastoma: A Promising Avenue for Therapeutic Intervention

BioChem Pub Date : 2024-06-06 DOI:10.3390/biochem4020007
Alhaji H. Janneh
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Abstract

Glioblastoma is the most common and aggressive type of malignant brain tumor with a poor prognosis due to the lack of effective treatment options. Therefore, new treatment options are required. Sphingolipids are essential components of the cell membrane, while complement components are integral to innate immunity, and both play a critical role in regulating glioblastoma survival signaling. This review focuses on recent studies investigating the functional roles of sphingolipid metabolism and complement activation signaling in glioblastoma. It also discusses how targeting these two systems together may emerge as a novel therapeutic approach.
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胶质母细胞瘤中的鞘脂信号传导和补体激活:治疗干预的希望之路
胶质母细胞瘤是最常见的侵袭性恶性脑肿瘤,由于缺乏有效的治疗方案,预后较差。因此,需要新的治疗方案。鞘磷脂是细胞膜的重要组成部分,而补体成分则是先天性免疫不可或缺的组成部分,二者在调节胶质母细胞瘤生存信号传导方面都起着至关重要的作用。这篇综述重点介绍了最近对胶质母细胞瘤中鞘脂代谢和补体激活信号功能作用的研究。它还讨论了将这两个系统作为靶点如何可能成为一种新的治疗方法。
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