Experimental Cranial Nerve Models in the Rat.

IF 2.2 3区医学 Q2 SURGERY Journal of reconstructive microsurgery Pub Date : 2025-02-01 Epub Date: 2024-06-18 DOI:10.1055/s-0044-1787729

Huseyin Karagoz, Feng Zhang, Sara C Chaker, William C Lineaweaver

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Abstract

Background: The intricacies of nerve regeneration following injury have prompted increased research efforts in recent years, with a primary focus on elucidating regeneration mechanisms and exploring various surgical techniques. While many experimental animals have been used for these investigations, the rat continues to remain the most widely used model due to its cost-effectiveness, accessibility, and resilience against diseases and surgical/anesthetic complications. A comprehensive evaluation of all the experimental rat models available in this context is currently lacking.

Methods: We summarize rat models of cranial nerves while furnishing descriptions of the intricacies of achieving optimal exposure.

Results: This review article provides an examination of the technical exposure, potential applications, and the advantages and disadvantages inherent to each cranial nerve model.

Conclusion: Specifically in the context of cranial nerve injury, numerous studies have utilized different surgical techniques to expose and investigate the cranial nerves in the rat.

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大鼠颅神经实验模型

背景：近年来，神经损伤后再生的复杂性促使人们加大了研究力度，主要重点是阐明再生机制和探索各种手术技术。虽然许多实验动物都被用于这些研究，但大鼠仍然是使用最广泛的模型，因为其成本效益高、容易获得、对疾病和手术/麻醉并发症有较强的抵抗力。目前还缺乏对所有可用的大鼠实验模型的全面评估：方法：我们总结了颅神经大鼠模型，同时描述了实现最佳暴露的复杂性：结果：这篇综述文章对每种颅神经模型的技术暴露、潜在应用和固有优缺点进行了研究：结论：在颅神经损伤方面，许多研究利用不同的手术技术来暴露和研究大鼠的颅神经。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of reconstructive microsurgery 医学-外科

CiteScore

4.50

自引率

28.60%

发文量

审稿时长

1 months

期刊介绍： The Journal of Reconstructive Microsurgery is a peer-reviewed, indexed journal that provides an international forum for the publication of articles focusing on reconstructive microsurgery and complex reconstructive surgery. The journal was originally established in 1984 for the microsurgical community to publish and share academic papers. The Journal of Reconstructive Microsurgery provides the latest in original research spanning basic laboratory, translational, and clinical investigations. Review papers cover current topics in complex reconstruction and microsurgery. In addition, special sections discuss new technologies, innovations, materials, and significant problem cases. The journal welcomes controversial topics, editorial comments, book reviews, and letters to the Editor, in order to complete the balanced spectrum of information available in the Journal of Reconstructive Microsurgery. All articles undergo stringent peer review by international experts in the specialty.