Facilitating the ethical sourcing of donor hematopoietic stem cells for cell and gene therapy research and development.

IF 2.4 4区医学 Q4 CELL & TISSUE ENGINEERING Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-06-18 DOI:10.1080/17460751.2024.2357930

Lina Hamad, Choon Key Chekar, Chloe Anthias, Laura Machin

引用次数: 0

Abstract

Aim: Unrelated stem cell donor registries (DRs) are increasingly engaging in the field of cell and gene therapy (CGT). This study aims to explore the values, concerns, needs and expectations of donors and members of the public on donating hematopoietic stem cells (HSCs) for CGT.Methods: Seven focus groups were conducted in 2019 with members of the public, prospective donors and donors on the Anthony Nolan DR in the UK.Results: Participants expressed concerns over increased frequency of donation and incidental findings and required more information on the type of research including the purpose and possible outcomes.Conclusion: Addressing donors' concerns, needs and expectations on donating cellular materials for CGT research and development is essential to maintaining the highest standards for donor care and safety within this rapidly emerging field.

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为细胞和基因疗法的研究与开发提供符合道德标准的造血干细胞捐献来源。

目的：非亲缘干细胞捐献者登记处（DRs）越来越多地参与到细胞和基因治疗（CGT）领域。本研究旨在探讨捐献者和公众对捐献造血干细胞用于细胞和基因治疗的价值观、关注点、需求和期望。研究方法于2019年与公众、潜在捐献者和英国安东尼诺兰DR的捐献者开展了七次焦点小组讨论。结果参与者对捐赠频率增加和偶然发现表示担忧，并要求获得更多有关研究类型的信息，包括目的和可能的结果。结论：解决捐献者对捐献细胞材料用于 CGT 研究和开发的担忧、需求和期望，对于在这一迅速崛起的领域保持最高标准的捐献者护理和安全至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative medicine 医学-工程：生物医学

CiteScore

4.20

自引率

3.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Regenerative medicine replaces or regenerates human cells, tissue or organs, to restore or establish normal function*. Since 2006, Regenerative Medicine has been at the forefront of publishing the very best papers and reviews covering the entire regenerative medicine sector. The journal focusses on the entire spectrum of approaches to regenerative medicine, including small molecule drugs, biologics, biomaterials and tissue engineering, and cell and gene therapies – it’s all about regeneration and not a specific platform technology. The journal’s scope encompasses all aspects of the sector ranging from discovery research, through to clinical development, through to commercialization. Regenerative Medicine uniquely supports this important area of biomedical science and healthcare by providing a peer-reviewed journal totally committed to publishing the very best regenerative medicine research, clinical translation and commercialization. Regenerative Medicine provides a specialist forum to address the important challenges and advances in regenerative medicine, delivering this essential information in concise, clear and attractive article formats – vital to a rapidly growing, multidisciplinary and increasingly time-constrained community. Despite substantial developments in our knowledge and understanding of regeneration, the field is still in its infancy. However, progress is accelerating. The next few decades will see the discovery and development of transformative therapies for patients, and in some cases, even cures. Regenerative Medicine will continue to provide a critical overview of these advances as they progress, undergo clinical trials, and eventually become mainstream medicine.