Cell type-specific control and post-translational regulation of specialized metabolism: opening new avenues for plant metabolic engineering

IF 8.3 2区 生物学 Q1 PLANT SCIENCES Current opinion in plant biology Pub Date : 2024-06-19 DOI:10.1016/j.pbi.2024.102575
Nikolaos Ntelkis , Alain Goossens , Krešimir Šola
{"title":"Cell type-specific control and post-translational regulation of specialized metabolism: opening new avenues for plant metabolic engineering","authors":"Nikolaos Ntelkis ,&nbsp;Alain Goossens ,&nbsp;Krešimir Šola","doi":"10.1016/j.pbi.2024.102575","DOIUrl":null,"url":null,"abstract":"<div><p>Although plant metabolic engineering enables the sustainable production of valuable metabolites with many applications, we still lack a good understanding of many multi-layered regulatory networks that govern metabolic pathways at the metabolite, protein, transcriptional and cellular level. As transcriptional regulation is better understood and often reviewed, here we highlight recent advances in the cell type-specific and post-translational regulation of plant specialized metabolism. With the advent of single-cell technologies, we are now able to characterize metabolites and their transcriptional regulators at the cellular level, which can refine our searches for missing biosynthetic enzymes and cell type-specific regulators. Post-translational regulation through enzyme inhibition, protein phosphorylation and ubiquitination are clearly evident in specialized metabolism regulation, but not frequently studied or considered in metabolic engineering efforts. Finally, we contemplate how advances in cell type-specific and post-translational regulation can be applied in metabolic engineering efforts <em>in planta</em>, leading to optimization of plants as metabolite production vehicles.</p></div>","PeriodicalId":11003,"journal":{"name":"Current opinion in plant biology","volume":"81 ","pages":"Article 102575"},"PeriodicalIF":8.3000,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in plant biology","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1369526624000669","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Although plant metabolic engineering enables the sustainable production of valuable metabolites with many applications, we still lack a good understanding of many multi-layered regulatory networks that govern metabolic pathways at the metabolite, protein, transcriptional and cellular level. As transcriptional regulation is better understood and often reviewed, here we highlight recent advances in the cell type-specific and post-translational regulation of plant specialized metabolism. With the advent of single-cell technologies, we are now able to characterize metabolites and their transcriptional regulators at the cellular level, which can refine our searches for missing biosynthetic enzymes and cell type-specific regulators. Post-translational regulation through enzyme inhibition, protein phosphorylation and ubiquitination are clearly evident in specialized metabolism regulation, but not frequently studied or considered in metabolic engineering efforts. Finally, we contemplate how advances in cell type-specific and post-translational regulation can be applied in metabolic engineering efforts in planta, leading to optimization of plants as metabolite production vehicles.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
细胞类型特异性控制和特化代谢的翻译后调控:为植物代谢工程开辟新途径
尽管植物代谢工程能够持续生产具有多种应用价值的代谢物,但我们仍然缺乏对许多多层次调控网络的充分了解,这些网络在代谢物、蛋白质、转录和细胞水平上调控着代谢途径。由于人们对转录调控有了更深入的了解,并经常对其进行回顾,因此我们在此重点介绍植物特化代谢的细胞类型特异性调控和翻译后调控方面的最新进展。随着单细胞技术的出现,我们现在能够在细胞水平上描述代谢物及其转录调控因子的特征,这可以完善我们对缺失的生物合成酶和细胞类型特异性调控因子的搜索。通过酶抑制、蛋白质磷酸化和泛素化进行翻译后调控在特异性代谢调控中非常明显,但在代谢工程工作中却不常研究或考虑。最后,我们将探讨如何将细胞特异性和翻译后调控方面的进展应用于植物体内的代谢工程,从而优化植物作为代谢物生产载体的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Current opinion in plant biology
Current opinion in plant biology 生物-植物科学
CiteScore
16.30
自引率
3.20%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Current Opinion in Plant Biology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating high quality reproducible research. It is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy - of editorial excellence, high-impact, and global reach - to ensure they are a widely read resource that is integral to scientists' workflow.
期刊最新文献
Grass awns: Morphological diversity arising from developmental constraint New perspectives of post-GWAS analyses: From markers to causal genes for more precise crop breeding Beat the heat: Breeding, genomics, and gene editing for high nighttime temperature tolerance in rice Gene regulatory networks in abiotic stress responses via single-cell sequencing and spatial technologies: Advances and opportunities Chitins and chitosans–A tale of discovery and disguise, of attachment and attainment
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1