Relationship between the clinical outcomes and the systemic inflammatory response index and systemic immune inflammation index after total knee arthroplasty.

Q1 Medicine MUSCULOSKELETAL SURGERY Pub Date : 2024-09-01 Epub Date: 2024-06-19 DOI:10.1007/s12306-024-00825-1

H Kürüm, S Key, H B Tosun, E Yılmaz, K O Kürüm, F İpekten, A Akcan

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Abstract

Background: Periprosthetic joint infection (PJI) is an extremely damaging complication that can occur after total knee arthroplasty (TKA). There is no study in the literature investigating the relationship between systemic inflammatory response index (SIRI) and systemic inflammation immune index (SII) values and prognosis and infection in patients who have undergone TKA. The aim of the study was to determine the relationship between the inflammatory index values and the rate of PJI in patients who had previously had TKA.

Methods: A total of 187 patients who underwent TKA between 2015 and 2023 years were retrospectively analyzed.

Results: The median value of the postoperative SII index was 1862.3 (1146.6-2630.4) in the infected group, while it was 1058.2 (605.0-1762.8) in the non-infected group (p < 0.001). In the infected group, the median value of preoperative SIRI was observed as 2.3 (1.7-3.5), while in the non-infected group it was 0.9 (0.7-1.5) (p < 0.001). The cutoff value for postoperative SIRI was observed to be 2.19, with a sensitivity value of 95%, a specificity value of 46%, the AUC value observed was 65%. The cutoff value for the postoperative SII index was observed to be 1058.96, with a sensitivity value of 100%, a specificity value of 50%.

Conclusions: Our study has associated the inflammatory markers SIRI, SII, neutrophil lymphocyte ratio, and platelet lymphocyte ratio with PJI, which are easy and inexpensive to obtain. There is no widely recognized serum biomarker that can be used alone with good sensitivity and specificity. This study contributes to finding the gold standard inflammatory marker for diagnosing PJI.

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全膝关节置换术后临床疗效与全身炎症反应指数和全身免疫炎症指数之间的关系。

背景：假体周围关节感染（PJI）是全膝关节置换术（TKA）后可能发生的一种危害极大的并发症。目前还没有文献研究全身炎症反应指数（SIRI）和全身炎症免疫指数（SII）值与 TKA 患者预后和感染之间的关系。该研究旨在确定曾接受过 TKA 的患者的炎症指数值与 PJI 发生率之间的关系：方法：对2015年至2023年间接受TKA的187名患者进行回顾性分析：结果：感染组术后SII指数中位值为1862.3（1146.6-2630.4），非感染组为1058.2（605.0-1762.8）（P 结论：我们的研究发现炎症标志物SII指数与TKA患者的炎症反应有关：我们的研究将炎症标志物 SIRI、SII、中性粒细胞淋巴细胞比值和血小板淋巴细胞比值与 PJI 联系起来，这些标志物容易获得且成本低廉。目前还没有一种被广泛认可的血清生物标志物可以单独使用，并具有良好的敏感性和特异性。这项研究有助于找到诊断 PJI 的金标准炎症标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

MUSCULOSKELETAL SURGERY Medicine-Surgery

CiteScore

4.50

自引率

0.00%

发文量

期刊介绍： Musculoskeletal Surgery – Formerly La Chirurgia degli Organi di Movimento, founded in 1917 at the Istituto Ortopedico Rizzoli, is a peer-reviewed journal published three times a year. The journal provides up-to-date information to clinicians and scientists through the publication of original papers, reviews, case reports, and brief communications dealing with the pathogenesis and treatment of orthopaedic conditions.An electronic version is also available at http://www.springerlink.com.The journal is open for publication of supplements and for publishing abstracts of scientific meetings; conditions can be obtained from the Editors-in-Chief or the Publisher.