Predictive capacity for local disease control of neogenin-1 (NEO1) transcriptional expression in patients with head and neck squamous cell carcinoma.

IF 2.8 3区医学 Q2 ONCOLOGY Clinical & Translational Oncology Pub Date : 2025-01-01 Epub Date: 2024-06-19 DOI:10.1007/s12094-024-03535-z

Xavier León, Cristina Valero, Gemma Fuster, Paloma Bragado, Mercedes Camacho, Francesc-Xavier Avilés-Jurado

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Abstract

Purpose: To analyze the predictive capacity for local disease control of the transcriptional expression of neogenin-1 (NEO1) gene in patients with head and neck squamous cell carcinoma (HNSCC).

Methods/patients: A retrospective study was performed on tumor biopsies from 107 patients with HNSCC treated surgically. The transcriptional expression of NEO1 was determined by RT-PCR. NEO1 transcriptional expression value was categorized according to local disease control by recursive partitioning analysis.

Results: Lower NEO1 transcriptional expression was associated with worse local control after surgical treatment. Patients with lower NEO1 expression (n = 25, 23.4%) had a 5-year local recurrence-free survival of 61.8% (95% CI: 42.1-81.5%), while patients with higher NEO1 expression (n = 82, 76.6%) had a 5-year local recurrence-free survival of 85.6% (95% CI: 77.6-93.6%), (P = 0.003). According to the result of multivariable analysis, patients with lower NEO1 expression had a 2.7-fold increased risk of local tumor recurrence (95% CI: 1.0-7.0, P = 0.043) compared to patients with higher NEO1 expression.

Conclusions: HNSCC patients with a lower transcriptional expression of NEO1 have a significantly higher risk of local recurrence after surgical treatment.

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头颈部鳞状细胞癌患者体内 neogenin-1 (NEO1) 转录表达对局部疾病控制的预测能力。

目的：分析头颈部鳞状细胞癌（HNSCC）患者体内neogenin-1（NEO1）基因转录表达对局部疾病控制的预测能力：对107名接受手术治疗的HNSCC患者的肿瘤活检组织进行了回顾性研究。通过 RT-PCR 检测 NEO1 的转录表达。通过递归分区分析，根据局部疾病控制情况对NEO1转录表达值进行分类：结果：较低的NEO1转录表达与手术治疗后较差的局部控制有关。NEO1表达较低的患者（n = 25，23.4%）5年无局部复发生存率为61.8%（95% CI：42.1-81.5%），而NEO1表达较高的患者（n = 82，76.6%）5年无局部复发生存率为85.6%（95% CI：77.6-93.6%），（P = 0.003）。多变量分析结果显示，与NEO1表达量较高的患者相比，NEO1表达量较低的患者局部肿瘤复发风险增加了2.7倍（95% CI：1.0-7.0，P = 0.043）：结论：NEO1转录表达较低的HNSCC患者手术治疗后局部复发的风险明显较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical & Translational Oncology 医学-肿瘤学

CiteScore

6.20

自引率

2.90%

发文量

240

审稿时长

1 months

期刊介绍： Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.