The diagnostic value of salivary C-reactive protein in neonatal infections: a meta-analysis.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES Infection Pub Date : 2024-10-01 Epub Date: 2024-06-21 DOI:10.1007/s15010-024-02328-4

Xinning Wang, Qiang Fei, Tianming Yuan

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Abstract

Purpose: C-reactive protein (CRP), as an acute phase protein, is a sensitive indicator of neonatal bacterial infection. Some recent studies have shown that there is a correlation between CRP levels in serum and saliva, and using saliva to detect CRP levels is expected to be an ideal and non-invasive method to predict neonatal infection. The purpose of this Meta-analysis was to evaluate the diagnostic value of salivary CRP for neonatal infection.

Methods: We searched PubMed, Embase, Web of Science, and Scopus databases in October 2023 and included observational studies that examined salivary CRP in newborns with bacterial infections. Data was extracted regarding the methodology, participant characteristics, and outcome measures.

Results: Nine articles were included, with a total of 696 newborns. Salivary CRP levels are significantly higher in neonates with infections compared to non-infected group (SMD = 0.58, 95%CI [0.40-0.76], P < 0.001). The accuracy for salivary CRP to predict serum CRP abnormality is high (sensitivity 86%, specificity 88%, area under the curve = 0.94).

Conclusions: Our meta-analysis suggested that salivary CRP can be used as an alternative biomarker to serum CRP for detecting neonatal infection.

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新生儿感染中唾液 C 反应蛋白的诊断价值：一项荟萃分析。

目的：C反应蛋白（CRP）作为一种急性期蛋白，是新生儿细菌感染的敏感指标。最近的一些研究表明，血清和唾液中的 CRP 水平存在相关性，利用唾液检测 CRP 水平有望成为预测新生儿感染的一种理想的无创方法。本 Meta 分析旨在评估唾液 CRP 对新生儿感染的诊断价值：方法：我们检索了2023年10月的PubMed、Embase、Web of Science和Scopus数据库，纳入了对患有细菌感染的新生儿唾液CRP进行检测的观察性研究。研究提取了有关方法、参与者特征和结果测量的数据：结果：共纳入 9 篇文章，涉及 696 名新生儿。与非感染组相比，感染新生儿的唾液 CRP 水平明显更高（SMD = 0.58，95%CI [0.40-0.76]，P我们的荟萃分析表明，唾液 CRP 可作为检测新生儿感染的血清 CRP 的替代生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.