Ecological validity of performance-based cognitive screeners in amyotrophic lateral sclerosis: preliminary evidence.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY Neurological Sciences Pub Date : 2024-11-01 Epub Date: 2024-06-21 DOI:10.1007/s10072-024-07660-z

Edoardo Nicolò Aiello, Silvia Torre, Federica Solca, Beatrice Curti, Giulia De Luca, Claudia Gendarini, Alessandro Cocuzza, Eleonora Colombo, Alessio Maranzano, Federico Verde, Claudia Morelli, Stefano Messina, Alberto Doretti, Vincenzo Silani, Nicola Ticozzi, Barbara Poletti

{"title":"Ecological validity of performance-based cognitive screeners in amyotrophic lateral sclerosis: preliminary evidence.","authors":"Edoardo Nicolò Aiello, Silvia Torre, Federica Solca, Beatrice Curti, Giulia De Luca, Claudia Gendarini, Alessandro Cocuzza, Eleonora Colombo, Alessio Maranzano, Federico Verde, Claudia Morelli, Stefano Messina, Alberto Doretti, Vincenzo Silani, Nicola Ticozzi, Barbara Poletti","doi":"10.1007/s10072-024-07660-z","DOIUrl":null,"url":null,"abstract":"Background: This study aimed at preliminarily assessing, in a cohort of non-demented amyotrophic lateral sclerosis (ALS) patients, the ecological validity, and more specifically the veridicality, of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and the ALS Cognitive Behavioral Screen (ALS-CBS™), by relating their scores to caregiver-report ratings of cognitive changes.Methods: N = 147 patient-caregiver dyads were recruited. Patients were administered the ECAS and ALS-CBS™, whilst caregiver the Caregiver Behavioral Questionnaire (CBQ) and Beaumont Behavioural Inventory (BBI). An Ecological Cognitive Functioning Index (ECFI) was derived from those items of the CBQ and BBI that tap on executive and language changes. Ecological validity was assessed via both correlational and predictive analyses net of caregiver-rated behavioural changes (as assessed by the ECAS-Carer Interview).Results: The ECFI was associated with the total scores on both the ECAS (p = .014) and ALS-CBS™ (p = .017). When looking at ECAS and ALS-CBS™ subscales, those assessing verbal fluency were selectively associated with the ECFI. The ECFI was higher in patients performing defectively on the ECAS (p = .004) and on the ALS-CBS™ (p = .027).Discussion: This study suggests that both the ECAS and the ALS-CBS™ represent a valid estimate of non-demented ALS patients' cognitive status in the real world, also highlighting the clinical relevance of cognitive changes reported by caregivers.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5319-5325"},"PeriodicalIF":2.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10072-024-07660-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/21 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: This study aimed at preliminarily assessing, in a cohort of non-demented amyotrophic lateral sclerosis (ALS) patients, the ecological validity, and more specifically the veridicality, of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and the ALS Cognitive Behavioral Screen (ALS-CBS™), by relating their scores to caregiver-report ratings of cognitive changes.

Methods: N = 147 patient-caregiver dyads were recruited. Patients were administered the ECAS and ALS-CBS™, whilst caregiver the Caregiver Behavioral Questionnaire (CBQ) and Beaumont Behavioural Inventory (BBI). An Ecological Cognitive Functioning Index (ECFI) was derived from those items of the CBQ and BBI that tap on executive and language changes. Ecological validity was assessed via both correlational and predictive analyses net of caregiver-rated behavioural changes (as assessed by the ECAS-Carer Interview).

Results: The ECFI was associated with the total scores on both the ECAS (p = .014) and ALS-CBS™ (p = .017). When looking at ECAS and ALS-CBS™ subscales, those assessing verbal fluency were selectively associated with the ECFI. The ECFI was higher in patients performing defectively on the ECAS (p = .004) and on the ALS-CBS™ (p = .027).

Discussion: This study suggests that both the ECAS and the ALS-CBS™ represent a valid estimate of non-demented ALS patients' cognitive status in the real world, also highlighting the clinical relevance of cognitive changes reported by caregivers.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

肌萎缩性脊髓侧索硬化症患者基于表现的认知筛选器的生态有效性：初步证据。

研究背景本研究旨在通过将爱丁堡认知和行为ALS筛查（ECAS）和ALS认知行为筛查（ALS-CBS™）的得分与护理人员报告的认知变化评分联系起来，初步评估非痴呆肌萎缩侧索硬化症（ALS）患者队列的生态有效性，更具体地说是真实性：方法：招募了 N = 147 个患者-护理者二人组。患者接受 ECAS 和 ALS-CBS™ 测试，护理者接受护理者行为问卷 (CBQ) 和博蒙特行为量表 (BBI) 测试。生态认知功能指数 (ECFI) 是根据 CBQ 和 BBI 中有关执行和语言变化的项目得出的。生态效度通过相关分析和预测分析对护理人员评定的行为变化（通过 ECAS 护理人员访谈进行评估）进行评估：ECFI与ECAS（p = .014）和ALS-CBS™（p = .017）的总分相关。从ECAS和ALS-CBS™的分量表来看，评估言语流畅性的分量表与ECFI有选择性关联。在ECAS（p = .004）和ALS-CBS™（p = .027）中表现不佳的患者ECFI较高：本研究表明，ECAS 和 ALS-CBS™ 均能有效评估非痴呆 ALS 患者在现实世界中的认知状况，同时也强调了护理人员报告的认知变化的临床相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.