Ex vivo Study of Partial Bladder Resection in a Porcine Model.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urologia Internationalis Pub Date : 2024-06-20 DOI:10.1159/000539836

Aleksander Kielbik, Timo Hoffmans, Bastian Amend, Arnulf Stenzl, Moritz Maas, Steffen Rausch, Stephan Kruck, Igor Tsaur, Stefan Aufderklamm

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Abstract

Introduction: Partial cystectomy aims to preserve bladder function, yet its urodynamic impacts remain unclear. We investigate these effects using an ex vivo porcine model, evaluating bladder volume, compliance, and wall thickness, alongside with thermal damage after bi- and monopolar resection.

Methods: Within an artificial human pelvis, we conducted partial bladder wall resections (5 cm2, 10 cm2). Urodynamic tests and sonography assessed volume, compliance, and thickness changes. Traction force for catheter retrieval and thermal collagen destruction were measured.

Results: Bladder compliance decreased by 1.12 and 1.5 after 5 cm2 and 10 cm2 resections, respectively, with volume reductions of 3-6% and 10-18%. Wall thickness decreased by 20% and 30% post-resection. Comparable thermal damage was observed with mono- and bipolar resection methods.

Conclusion: Our study outlines urodynamic impacts and technical considerations of partial cystectomy, affirming its endoscopic feasibility while highlighting potential bladder dysfunction risks.

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猪模型膀胱部分切除术的体内外研究猪模型膀胱部分切除术的体内外研究。

导言：膀胱部分切除术旨在保留膀胱功能，但其尿动力学影响仍不明确。我们使用体外猪模型研究了这些影响，评估了膀胱容量、顺应性和壁厚，以及双极和单极切除后的热损伤：我们在人造人骨盆内进行了部分膀胱壁切除术（5 平方厘米和 10 平方厘米）。尿动力学测试和超声波检查评估了容量、顺应性和厚度的变化。测量了导管取出时的牵引力和热胶原破坏情况：结果：5 平方厘米和 10 平方厘米切除术后，膀胱顺应性分别降低了 1.12 和 1.5，容量分别减少了 3-6% 和 10-18%。切除后膀胱壁厚度分别减少了 20% 和 30%。单极和双极切除法观察到的热损伤相当：我们的研究概述了膀胱部分切除术的尿动力学影响和技术注意事项，肯定了其内窥镜可行性，同时强调了潜在的膀胱功能障碍风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urologia Internationalis 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.