Chitosan decorated oleosomes loaded propranolol hydrochloride hydrogel repurposed for Candida albicans-vaginal infection.

Nanomedicine (London, England) Pub Date : 2024-06-20 DOI:10.1080/17435889.2024.2359364

Moaz A Eltabeeb, Menna M Abdellatif, Mohamed A El-Nabarawi, Mahmoud H Teaima, Mohammed I A Hamed, Khaled M Darwish, Mariam Hassan, Ahmed Me Hamdan, Raghda Rabe Hamed

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Abstract

Aim: Our investigation aims to estimate the antifungal effect of propranolol hydrochloride (PNL). Methods: Oleosomes (OLs) were fabricated by thin-film hydration and evaluated for entrapment efficiency (EE%), particle size (PS), polydispersity index (PDI), zeta potential (ZP), and amount of drug released after 6 h Q6h (%). Results: The optimal OL showed a rounded shape with optimum characteristics. The ex-vivo permeation and confocal laser scanning microscopy verified the prolonged release and well deposition of PNL-loaded OLs-gel. The in-silico assessment demonstrated the good stability of PNL with OLs' ingredients. In vivo evaluations for PNL-loaded OLs-gel showed a good antifungal impact against Candida albicans with good safety. Conclusion: This work highlights the potential of PNL-loaded OLs-gel as a potential treatment for candida vaginal infection.

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壳聚糖装饰的油小体负载盐酸普萘洛尔氢凝胶被重新用于治疗白色念珠菌阴道感染。

目的：我们的调查旨在评估盐酸普萘洛尔（PNL）的抗真菌效果。方法：采用薄膜水合法制造油小体（OLs），并评估其抗真菌效果（单位：mg/g）：通过薄膜水合法制备油小体（OLs），并评估其包载效率（EE%）、粒度（PS）、多分散指数（PDI）、Zeta 电位（ZP）以及 6 小时 Q6h 后的药物释放量（%）。结果显示最佳 OL 呈圆形，具有最佳特性。体内外渗透和共聚焦激光扫描显微镜验证了负载 PNL 的 OLs-凝胶的长期释放和良好沉积。室内评估表明，PNL 与 OL 成分具有良好的稳定性。载入 PNL 的 OLs-凝胶的体内评估显示，它对白色念珠菌具有良好的抗真菌效果，而且安全性良好。结论这项研究强调了 PNL 负载 OLs-凝胶作为治疗念珠菌阴道感染的潜在药物的潜力。

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Nanomedicine (London, England)

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