Seizure and coma with overdose dextromethorphan: A case report

Brain and Development Case Reports Pub Date : 2024-06-21 DOI:10.1016/j.bdcasr.2024.100027

Ken Nakano , Shingo Numoto , Akihisa Okumura , Kazuhiro Hirata , Sachie Kaneko , Yoichiro Oro

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Abstract

Background

Dextromethorphan (DXM) is a commonly used anti-tussive drug. DXM overdose can elicit neurobehavioral effects, such as hallucinations, stimulation, euphoria, and dissociation, and rarely cause seizures or coma.

Case report

A 14-year-old Japanese female was referred to the emergency department of our hospital in a coma following a seizure. She had no history of epilepsy or psychiatric diseases. Initially, the underlying causes of the coma and seizures were unclear. However, several used DXM packages were found in her school bag, and an overdose was suspected. The patient was diagnosed with DXM overdose. The neurobehavioral symptoms resolved without specific treatments. DXM concentrations in the blood and cerebrospinal fluid were 830 and 320 ng/mL, respectively.

Conclusion

The possibility of DXM overdose should be considered in patients admitted with seizures or comas of unknown cause.

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过量使用右美沙芬导致癫痫发作和昏迷：病例报告

背景右美沙芬（DXM）是一种常用的抗惊厥药物。病例报告一名 14 岁的日本女性在癫痫发作后昏迷不醒，被转诊到我院急诊科。她没有癫痫或精神病史。最初，昏迷和癫痫发作的根本原因并不清楚。然而，在她的书包里发现了几包用过的 DXM，怀疑是用药过量所致。患者被诊断为 DXM 药物过量。神经行为症状无需特殊治疗即可缓解。血液和脑脊液中的 DXM 浓度分别为 830 纳克/毫升和 320 纳克/毫升。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Brain and Development Case Reports

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