Efficacy of 100 hz sound stimulation on saccular dysfunction in meniere's disease.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-04-01 Epub Date: 2024-06-24 DOI:10.1080/00016489.2024.2363462

Michihiko Sone, Nobutaka Ohgami, Naomi Katayama, Masumi Kobayashi, Yishuo Gu, Keming Tong, Tadao Yoshida, Shinji Naganawa, Masashi Kato

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Abstract

Background: Although various medical remedies have been attempted to alleviate the symptoms of Meniere's disease (MD), the risk-benefit ratios of these various treatments remain debatable.

Objective: We investigated the efficacy of sound stimulation of 100 Hz for treating vestibular dysfunction in patients with Meniere's disease (MD).

Materials and methods: Patients with definitive MD with intractable vestibular symptoms and endolymphatic hydrops (EH) in the inner ear were evaluated. The experimental group received sound stimulation of 75 dB at a frequency of 100 Hz for 5 min, and the control group received sound stimulation of 75 dB at a frequency of 250 Hz for 5 min. Cervical vestibular-evoked myogenic potentials (cVEMPs) were measured before and after each sound stimulation, and the results of the clinical tests were compared between the two patient groups.

Results: Significant increases in cVEMP amplitudes were observed after sound stimulation of 100 Hz in ears with vestibular endolymphatic hydrops, although no such improvement was observed in the control group.

Conclusion: Sound stimulation of 75 dB at a frequency of 100 Hz leads to improvement in cVEMP amplitude in patients with definitive MD. Adequate sound stimulation might be a new method for treating vestibular dysfunction associated with MD.

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100赫兹声音刺激对梅尼埃病囊管功能障碍的疗效。

背景：尽管人们尝试了各种医疗方法来缓解梅尼埃病（MD）的症状，但这些不同治疗方法的风险效益比仍存在争议：我们研究了 100 赫兹声刺激治疗梅尼埃病（MD）患者前庭功能障碍的疗效：我们对具有顽固性前庭症状和内耳内淋巴水肿（EH）的确诊梅尼埃病患者进行了评估。实验组接受频率为 100 Hz、75 dB 的声音刺激 5 分钟，对照组接受频率为 250 Hz、75 dB 的声音刺激 5 分钟。在每次声音刺激前后测量颈前庭诱发肌源性电位（cVEMPs），并比较两组患者的临床测试结果：结果：对前庭内淋巴水肿患者的耳朵进行 100 赫兹的声音刺激后，cVEMP 振幅明显增加，而对照组患者的 cVEMP 振幅则没有改善：结论：频率为 100 Hz 的 75 dB 声音刺激可改善确诊 MD 患者的 cVEMP 幅值。适当的声音刺激可能是治疗与 MD 相关的前庭功能障碍的一种新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.