The emerging and diverse roles of F-box proteins in spermatogenesis and male infertility.

IF 4 Q2 CELL & TISSUE ENGINEERING Cell Regeneration Pub Date : 2024-06-26 DOI:10.1186/s13619-024-00196-9
Xuan Zhuang, Jun Ruan, Canquan Zhou, Zhiming Li
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Abstract

F-box proteins play essential roles in various cellular processes of spermatogenesis by means of ubiquitylation and subsequent target protein degradation. They are the substrate-recognition subunits of SKP1-cullin 1-F-box protein (SCF) E3 ligase complexes. Dysregulation of F‑box protein‑mediated proteolysis could lead to male infertility in humans and mice. The emerging studies revealed the physiological function, pathological evidence, and biochemical substrates of F-box proteins in the development of male germ cells, which urging us to review the current understanding of how F‑box proteins contribute to spermatogenesis. More functional and mechanistic study will be helpful to define the roles of F-box protein in spermatogenesis, which will pave the way for the logical design of F-box protein-targeted diagnosis and therapies for male infertility, as the spermatogenic role of many F-box proteins remains elusive.

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F-box 蛋白在精子发生和男性不育中新出现的多种作用。
F-box 蛋白通过泛素化和随后的靶蛋白降解,在精子发生的各种细胞过程中发挥着重要作用。它们是 SKP1-Cullin 1-F-box 蛋白(SCF)E3 连接酶复合物的底物识别亚基。F-box 蛋白介导的蛋白水解失调可导致人类和小鼠的雄性不育。新的研究揭示了 F-box 蛋白在男性生殖细胞发育过程中的生理功能、病理证据和生化底物,这促使我们重新审视目前对 F-box 蛋白如何促进精子发生的认识。更多的功能和机理研究将有助于明确F-box蛋白在精子发生中的作用,这将为F-box蛋白靶向诊断和治疗男性不育症的合理设计铺平道路,因为许多F-box蛋白的生精作用仍然难以捉摸。
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来源期刊
Cell Regeneration
Cell Regeneration Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
5.80
自引率
0.00%
发文量
42
审稿时长
35 days
期刊介绍: Cell Regeneration aims to provide a worldwide platform for researches on stem cells and regenerative biology to develop basic science and to foster its clinical translation in medicine. Cell Regeneration welcomes reports on novel discoveries, theories, methods, technologies, and products in the field of stem cells and regenerative research, the journal is interested, but not limited to the following topics: ◎ Embryonic stem cells ◎ Induced pluripotent stem cells ◎ Tissue-specific stem cells ◎ Tissue or organ regeneration ◎ Methodology ◎ Biomaterials and regeneration ◎ Clinical translation or application in medicine
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