A Ranking Tool for "Category Killer" Microbial Biobanks.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-06-26 DOI:10.1089/bio.2024.0027

Martin Boutroux, Adriana Chiarelli, Mariana L Ferrari, Olivier Chesneau, Dominique Clermont, Fay Betsou

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Abstract

Microbial biobanks preserve and provide microbial bioresources for research, training, and quality control purposes. They ensure the conservation of biodiversity, contribute to taxonomical research, and support scientific advancements. Microbial biobanks can cover a wide range of phylogenetic and metabolic diversity ("category killers") or focus on specific taxonomic, thematic, or disease areas. The strategic decisions about strain selection for certain applications or for the biobank culling necessitate a method to support prioritization and selection. Here, we propose an unbiased scoring approach based on objective parameters to assess, categorize, and assign priorities among samples in stock in a microbial biobank. We describe the concept of this ranking tool and its application to identify high-priority strains for whole genome sequencing with two main goals: (i) genomic characterization of quality control, reference, and type strains; (ii) genome mining for the discovery of natural products, bioactive and antimicrobial molecules, with focus on human diseases. The general concept of the tool can be useful to any biobank and for any ranking or culling needs.

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类别杀手 "微生物生物库排名工具。

微生物生物库为研究、培训和质量控制目的保存和提供微生物生物资源。它们可确保生物多样性的保护，促进分类研究，支持科学进步。微生物生物库可以涵盖广泛的系统发育和代谢多样性（"类别杀手"），也可以侧重于特定的分类、专题或疾病领域。为某些应用或生物库筛选菌株的战略决策需要一种方法来支持优先排序和选择。在此，我们提出一种基于客观参数的无偏见评分方法，用于对微生物生物库中的库存样本进行评估、分类和优先级分配。我们描述了这一排序工具的概念及其在确定高优先级菌株以进行全基因组测序中的应用，其主要目标有两个：(i) 质量控制、参考和类型菌株的基因组特征；(ii) 基因组挖掘，以发现天然产品、生物活性和抗菌分子，重点是人类疾病。该工具的总体概念可用于任何生物库，满足任何排序或剔除需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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