PPInterface: A Comprehensive Dataset of 3D Protein-Protein Interface Structures

IF 4.7 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Molecular Biology Pub Date : 2024-09-01 DOI:10.1016/j.jmb.2024.168686

引用次数: 0

Abstract

The PPInterface dataset contains 815,082 interface structures, providing the most comprehensive structural information on protein–protein interfaces. This resource is extracted from over 215,000 three-dimensional protein structures stored in the Protein Data Bank (PDB). The dataset contains a wide range of protein complexes, providing a wealth of information for researchers investigating the structural properties of protein–protein interactions. The accompanying web server has a user-friendly interface that allows for efficient search and download functions. Researchers can access detailed information on protein interface structures, visualize them, and explore a variety of features, increasing the dataset’s utility and accessibility.

The dataset and web server can be found at https://3dpath.ku.edu.tr/PPInt/.

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PPInterface：三维蛋白质-蛋白质界面结构综合数据集。

PPInterface 数据集包含 815,082 个界面结构，提供了最全面的蛋白质-蛋白质界面结构信息。该资源提取自蛋白质数据库（PDB）中存储的 215,000 多个三维蛋白质结构。该数据集包含各种蛋白质复合物，为研究蛋白质-蛋白质相互作用结构特性的研究人员提供了丰富的信息。配套的网络服务器具有用户友好的界面，可实现高效的搜索和下载功能。研究人员可以获取蛋白质界面结构的详细信息，将其可视化，并探索各种功能，从而提高数据集的实用性和可访问性。数据集和网络服务器可在 https://3dpath.ku.edu.tr/PPInt/ 上找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Biology 生物-生化与分子生物学

CiteScore

11.30

自引率

1.80%

发文量

412

审稿时长

28 days

期刊介绍： Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions. Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.

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