The effect of lactoferin on the free radical and cytokine status of cornea in the experimental thermal burn.

Q3 Biochemistry, Genetics and Molecular Biology Biomeditsinskaya khimiya Pub Date : 2024-06-01 DOI:10.18097/PBMC20247003168
I V Kirsanova, A V Kolesnikov, A V Shchulkin, Yu V Abalenikhina, P D Erokhina, E N Yakusheva
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Abstract

The free radical and cytokine statuses of the cornea during its thermal burn and the possibility of its correction by lactoferrin have been studied in Soviet Chinchilla rabbits. The development of a corneal thermal burn was accompanied by the development of oxidative stress (increased levels of TBA-reactive substances and carbonyl derivatives of proteins, decreased activity of SOD and GPx enzymes) and a pronounced inflammatory reaction with increased levels of TNF-1α, IL-10, TGF-1β. The use of lactoferrin had a pronounced therapeutic effect, which was manifested by accelerated healing, prevention of the development of complications (corneal perforations), a decrease in the severity of oxidative stress, an increase in the concentrations of TNF-1α (in the early stages), IL-10 (in the later stages), TGF-1β (throughout the experiment). At the same time, by the end of regeneration more severe corneal opacification was recognized compared to the control group. This may be associated with an increased level of anti-inflammatory cytokines, especially TGF-1β.

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乳铁蛋白对实验性热烧伤角膜自由基和细胞因子状态的影响
我们在苏联栗鼠兔身上研究了角膜热灼伤时的自由基和细胞因子状态,以及乳铁蛋白纠正这种状态的可能性。角膜热灼伤伴随着氧化应激的发展(TBA反应物质和蛋白质羰基衍生物水平升高,SOD和GPx酶活性降低)和明显的炎症反应,TNF-1α、IL-10、TGF-1β水平升高。使用乳铁蛋白有明显的治疗效果,表现为加速愈合,防止并发症(角膜穿孔)的发生,降低氧化应激的严重程度,增加 TNF-1α(早期阶段)、IL-10(后期阶段)、TGF-1β(整个实验期间)的浓度。同时,与对照组相比,再生结束时角膜不透明的情况更为严重。这可能与抗炎细胞因子(尤其是 TGF-1β)水平升高有关。
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来源期刊
Biomeditsinskaya khimiya
Biomeditsinskaya khimiya Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
CiteScore
1.30
自引率
0.00%
发文量
49
期刊介绍: The aim of the Russian-language journal "Biomeditsinskaya Khimiya" (Biomedical Chemistry) is to introduce the latest results obtained by scientists from Russia and other Republics of the Former Soviet Union. The Journal will cover all major areas of Biomedical chemistry, including neurochemistry, clinical chemistry, molecular biology of pathological processes, gene therapy, development of new drugs and their biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine etc. The Journal also publish review articles. All issues of journal usually contain invited reviews. Papers written in Russian contain abstract (in English).
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