Advancements in enzymatic biotransformation and bioactivities of rare ginsenosides: A review

IF 4.1 2区 生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of biotechnology Pub Date : 2024-06-28 DOI:10.1016/j.jbiotec.2024.06.018
Yanbo Hu , Yiming Li , Yi Cao , Yuzhu Shen , Xianjun Zou , Jiaxin Liu , Jun Zhao
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Abstract

Ginsenoside, the principal active constituent of ginseng, exhibits enhanced bioavailability and medicinal efficacy in rare ginsenosides compared to major ginsenosides. Current research is focused on efficiently and selectively removing sugar groups attached to the major ginsenoside sugar chains to convert them into rare ginsenosides that meet the demands of medical industry and functional foods. The methods for preparing rare ginsenosides encompass chemical, microbial, and enzymatic approaches. Among these, the enzyme conversion method is highly favored by researchers due to its exceptional specificity and robust efficiency. This review summarizes the biological activities of different rare ginsenosides, explores the various glycosidases used in the biotransformation of different major ginsenosides as substrates, and elucidates their respective corresponding biotransformation pathways. These findings will provide valuable references for the development, utilization, and industrial production of ginsenosides.

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稀有人参皂苷的酶生物转化和生物活性研究进展:综述。
人参皂甙是人参的主要活性成分,与主要人参皂甙相比,稀有人参皂甙具有更高的生物利用度和药效。目前的研究重点是高效、选择性地去除附着在主要人参皂甙糖链上的糖基,将其转化为稀有人参皂甙,以满足医疗行业和功能食品的需求。制备稀有人参皂苷的方法包括化学、微生物和酶法。其中,酶转化法因其特异性强、效率高而备受研究人员青睐。本综述总结了不同稀有人参皂甙的生物活性,探讨了以不同主要人参皂甙为底物进行生物转化时使用的各种糖苷酶,并阐明了它们各自相应的生物转化途径。这些发现将为人参皂苷的开发、利用和工业化生产提供有价值的参考。
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来源期刊
Journal of biotechnology
Journal of biotechnology 工程技术-生物工程与应用微生物
CiteScore
8.90
自引率
2.40%
发文量
190
审稿时长
45 days
期刊介绍: The Journal of Biotechnology has an open access mirror journal, the Journal of Biotechnology: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. The Journal provides a medium for the rapid publication of both full-length articles and short communications on novel and innovative aspects of biotechnology. The Journal will accept papers ranging from genetic or molecular biological positions to those covering biochemical, chemical or bioprocess engineering aspects as well as computer application of new software concepts, provided that in each case the material is directly relevant to biotechnological systems. Papers presenting information of a multidisciplinary nature that would not be suitable for publication in a journal devoted to a single discipline, are particularly welcome.
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