{"title":"A new cassane diterpenoid from the seed of <i>Caesalpinia sappan</i>.","authors":"Yue-Lin Zhao, Yue Jin, Zi-Ying Han, Wen-Han Song, Hui-Lin Zhu, Jian Zhang, Qian Wang, Miao Wang, Xiao-Wen Jiang, Hui-Yuan Gao","doi":"10.1080/10286020.2024.2360640","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (<b>1</b>), along with two known cassane diterpenoids caesanine C (<b>2</b>) and tomocinol B (<b>3</b>), was isolated from 95% EtOH extract of the seeds of <i>Caesalpinia sappan</i> Linn. Additionally, three known compounds including pulcherrin R (<b>4</b>), syringaresinol-4'-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>5</b>) and kaempferol (<b>6</b>) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound <b>1</b>. Among the isolated compounds, compound <b>1</b> displayed a potent anti-neuroinflammation with an IC<sub>50</sub> value of 9.87 ± 1.71 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2024.2360640","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
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Abstract
In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (1), along with two known cassane diterpenoids caesanine C (2) and tomocinol B (3), was isolated from 95% EtOH extract of the seeds of Caesalpinia sappan Linn. Additionally, three known compounds including pulcherrin R (4), syringaresinol-4'-O-β-D-glucopyranoside (5) and kaempferol (6) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound 1. Among the isolated compounds, compound 1 displayed a potent anti-neuroinflammation with an IC50 value of 9.87 ± 1.71 μM.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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