[Structure and Evolution of DNA Transposons of the L31 Superfamily in Bivalves].

M V Puzakov, L V Puzakova
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Abstract

The mobile genetic elements IS630/Tc 1/mariner (ITm) are widespread DNA transposons that make a significant contribution to the evolution of eukaryotic genomes. With the start of large-scale application of next-generation sequencing (NGS) technologies and the emergence of many new whole genome sequences of organisms in nucleotide sequence collections, the ITm elements have been identified in most taxa of the eukaryotic tree of life. Although ITm diversity has been studied in detail, new elements are still found, thus expanding the respective DNA transposon group and calling for review of its classification. Bivalve L31 elements were for the first time analyzed in detail to describe their structures, diversity, distribution, and phylogenetic position among the ITm elements. The L31 transposons were found to form an independent superfamily of an ancient origin within the ITm group. Rather high diversity was observed within the L31 clade; i.e., five phylogenetic clusters were identified. In mollusks, the L31 transposons have been detected only in the subclass Autobranchia and predominate in diversity and number in the infraclass Pteriomorphia. A protein encoded by open reading frame 2 (ORF2) was shown to be an integral structural component of almost all full-length L31 elements. The results provide for a better understanding of the evolution of particular ITm transposons. Further study of the L31 transposons in other taxa (cnidarians) and functional investigation of the ORF2 protein product will help to better understand the evolution of DNa transposons, the mechanisms of their horizontal transfer, and their contribution to eukaryotic biodiversity.

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[双壳类 L31 超家族 DNA 转座子的结构与进化]。
移动遗传因子IS630/Tc 1/mariner(ITm)是一种广泛存在的DNA转座子,对真核生物基因组的进化做出了重要贡献。随着新一代测序(NGS)技术的大规模应用以及核苷酸序列库中许多新的生物全基因组序列的出现,ITm元件已在真核生物生命树的大多数类群中被鉴定出来。尽管对 ITm 的多样性进行了详细研究,但仍有新的元素被发现,从而扩大了 DNA 转座子组的范围,并要求对其分类进行审查。我们首次详细分析了双壳类 L31 元子,以描述它们的结构、多样性、分布以及在 ITm 元子中的系统发育位置。研究发现,L31 转座子在 ITm 群体中形成了一个独立的、起源古老的超家族。在 L31 支系中观察到了相当高的多样性,即发现了五个系统发生群。在软体动物中,L31 转座子只在自鳃亚纲中被发现,在翼手目亚纲中则以多样性和数量居多。研究结果表明,开放阅读框 2(ORF2)编码的蛋白质是几乎所有全长 L31 转座子的结构组成部分。这些结果有助于更好地了解特定 ITm 转座子的进化过程。对其他类群(刺胞动物)的 L31 转座子的进一步研究和 ORF2 蛋白产物的功能调查将有助于更好地理解 DNa 转座子的进化、其水平转移的机制及其对真核生物多样性的贡献。
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DNA transposons and the evolution of eukaryotic genomes.
IF 11.1 1区 生物学Annual review of geneticsPub Date : 2007-01-01 DOI: 10.1146/annurev.genet.40.110405.090448
Cédric Feschotte, Ellen J Pritham
Structure and Evolution of DNA Transposons of the L31 Superfamily in Bivalves
IF 1.2 4区 生物学Molecular BiologyPub Date : 2024-03-07 DOI: 10.1134/s0026893324010114
M. V. Puzakov, L. V. Puzakova
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Molekulyarnaya Biologiya
Molekulyarnaya Biologiya Medicine-Medicine (all)
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0.70
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0.00%
发文量
131
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