Prevention of Chronic Diabetic Neuropathy and Diabetes-Associated Cognitive Impairment Using Medicinal Herbs (Cassia Angustifolia and Nigella Sativa).

IF 2.5 3区 工程技术 Q2 BIOLOGY Yale Journal of Biology and Medicine Pub Date : 2024-06-28 eCollection Date: 2024-06-01 DOI:10.59249/UQLO8012
Mahum Khan, Hibba Riaz, Faria Hasan Jatala, Aneeqa Noor, Sara Mumtaz, Saima Zafar
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Abstract

Nodal regions, areas of intensive contact between Schwann cells and axons, may be exceptionally vulnerable to diabetes-induced changes because they are exposed to and impacted by the metabolic implications of diabetes. Insulin receptors, glucose transporters, Na+ and K+ channels, and mitochondria are abundant in nodes, all of which have been linked to the development and progression of Diabetic Peripheral Neuropathy (DPN) and Type 1 Diabetes Mellitus (T1DM)-associated cognitive impairment. Our study aimed to evaluate if the administration of Nigella sativa (NS) and Cassia angustifolia (CA) prevented diabetes-associated nervous system deficits in hyperglycemic mice. We developed T1DM mice through Streptozotocin (STZ) injections and validated the elevations in blood glucose levels. NS and CA were administered immediately upon the induction of diabetes. Behavioral analysis, histopathological evaluations, and assessment of molecular biomarkers (NR2A, MPZ, NfL) were performed to assess neuropathy and cognitive impairment. Improvements in memory, myelin loss, and the expression of synaptic proteins, even with the retention of hyperglycemia, were evident in the mice who were given a dose of herbal products upon the detection of hyperglycemia. NS was more beneficial in preventing memory impairments, demyelination, and synaptic dysfunction. The findings indicate that including these herbs in the diets of diabetic as well as pre-diabetic patients can reduce complications associated with T1DM, notably diabetic peripheral neuropathy and cognitive deficits associated with T1DM.

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用药草(决明子和黑木耳)预防慢性糖尿病神经病变和与糖尿病相关的认知障碍
结节区是许旺细胞和轴突密集接触的区域,可能特别容易受到糖尿病引起的变化的影响,因为它们暴露在糖尿病的代谢影响之下并受到其影响。胰岛素受体、葡萄糖转运体、Na+和K+通道以及线粒体在结节中大量存在,所有这些都与糖尿病周围神经病变(DPN)和1型糖尿病(T1DM)相关认知障碍的发生和发展有关。我们的研究旨在评估给高血糖小鼠服用黑麦草(NS)和决明子(CA)是否能预防糖尿病相关神经系统缺陷。我们通过注射链脲佐菌素(STZ)培育了 T1DM 小鼠,并验证了血糖水平的升高。诱导糖尿病后立即注射 NS 和 CA。进行行为分析、组织病理学评估和分子生物标记物(NR2A、MPZ、NfL)评估,以评估神经病变和认知障碍。在检测到高血糖时给小鼠服用一定剂量的草药产品,即使高血糖仍然存在,小鼠的记忆力、髓鞘脱落和突触蛋白的表达都有明显改善。NS更有利于防止记忆损伤、脱髓鞘和突触功能障碍。研究结果表明,在糖尿病患者和糖尿病前期患者的饮食中加入这些草药可减少与 T1DM 相关的并发症,尤其是与 T1DM 相关的糖尿病周围神经病变和认知障碍。
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来源期刊
Yale Journal of Biology and Medicine
Yale Journal of Biology and Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
5.00
自引率
0.00%
发文量
41
期刊介绍: The Yale Journal of Biology and Medicine (YJBM) is a graduate and medical student-run, peer-reviewed, open-access journal dedicated to the publication of original research articles, scientific reviews, articles on medical history, personal perspectives on medicine, policy analyses, case reports, and symposia related to biomedical matters. YJBM is published quarterly and aims to publish articles of interest to both physicians and scientists. YJBM is and has been an internationally distributed journal with a long history of landmark articles. Our contributors feature a notable list of philosophers, statesmen, scientists, and physicians, including Ernst Cassirer, Harvey Cushing, Rene Dubos, Edward Kennedy, Donald Seldin, and Jack Strominger. Our Editorial Board consists of students and faculty members from Yale School of Medicine and Yale University Graduate School of Arts & Sciences. All manuscripts submitted to YJBM are first evaluated on the basis of scientific quality, originality, appropriateness, contribution to the field, and style. Suitable manuscripts are then subject to rigorous, fair, and rapid peer review.
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