Lobe-Based Hepatic Uptake Index of Gd-EOB-DTPA on Contrast-Enhanced MRI to Quantitatively Discriminate between Compensated and Decompensated Hepatitis B-Related Cirrhosis.

IF 2.7 4区医学 Q2 Medicine Canadian Journal of Gastroenterology and Hepatology Pub Date : 2024-06-21 eCollection Date: 2024-01-01 DOI:10.1155/2024/6623848

Fulin Lu, Bangguo Tan, Yucheng Huang, Lin Xu, Changqiang Wu, Haiying Zhou, Rui Li, Xiaoming Zhang, Tianwu Chen, Hongjun Li

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引用次数: 0

Abstract

Purpose: To use hepatic uptake index (HUI) of liver lobes on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) to discriminate between patients with hepatitis B-related cirrhosis in compensated and decompensated statuses.

Methods: Forty-four consecutive patients with hepatitis B-related cirrhosis who underwent Gd-EOB-DTPA-enhanced MRI were divided into compensated and decompensated statuses based on clinical evaluation. Volume and signal intensity of individual lobes were retrospectively measured to calculate HUI of the right liver lobe (RHUI), medial (MHUI) and lateral (LHUI) left liver lobes, and caudate lobe (CHUI). Spearman's rank correlation analyses were performed to evaluate relationships of lobe-based HUI with Child-Pugh and model for end-stage liver disease (MELD) scoring system scores in compensated and decompensated statuses. The Mann-Whitney U-test was used to compare the lobe-based HUI between compensated and decompensated statuses. The performance of lobe-based HUI in distinguishing cirrhosis was evaluated using receiver operating characteristic (ROC) analysis, and the area under the ROC curve (AUC) was calculated as a measure of accuracy. Delong's method was used for statistical analysis to elucidate which HUI is optimal.

Results: Compensated and decompensated liver cirrhosis were confirmed in 25 (56.82%) and 19 (43.18%) patients, respectively. According to Spearman's rank correlation analysis, RHUI, MHUI, LHUI, and CHUI were all significantly associated with Child-Pugh and MELD scores (all P values <0.05). Receiver operating characteristic analysis demonstrated that among all lobe-based HUI parameters, RHUI could best perform the previous discrimination with a cut-off of 485.73 and obtain an AUC of 0.867. The AUC of RHUI improved and was significantly different from that of MHUI, LHUI, and CHUI (P = 0.03, P = 0.007, and P < 0.001, respectively, Delong's test).

Conclusions: The RHUI could help quantitatively discriminate hepatitis B-related cirrhosis between compensated and decompensated statuses.

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对比增强磁共振成像中基于肝叶的 Gd-EOB-DTPA 肝摄取指数定量区分乙肝相关肝硬化的代偿期和失代偿期

目的：利用钆乙氧苄基二乙三胺五乙酸（Gd-EOB-DTPA）增强磁共振成像（MRI）上的肝叶摄取指数（HUI）来区分乙肝相关肝硬化患者的代偿期和失代偿期：根据临床评估结果，将连续接受 Gd-EOB-DTPA 增强 MRI 检查的 44 例乙肝相关肝硬化患者分为代偿期和失代偿期。通过回顾性测量单个肝叶的体积和信号强度，计算右肝叶（RHUI）、左肝叶内侧（MHUI）和外侧（LHUI）以及尾状叶（CHUI）的 HUI。进行斯皮尔曼等级相关分析，以评估在代偿和失代偿状态下，基于肝叶的 HUI 与 Child-Pugh 和终末期肝病模型（MELD）评分系统评分的关系。曼-惠特尼 U 检验用于比较代偿期和失代偿期的肝叶 HUI。使用接收器操作特征（ROC）分析评估了基于肝叶的 HUI 在区分肝硬化方面的性能，并计算了 ROC 曲线下面积（AUC）作为准确性的衡量标准。德隆法用于统计分析，以阐明哪种 HUI 最佳：分别有 25 例（56.82%）和 19 例（43.18%）患者确诊为肝硬化代偿期和失代偿期。根据斯皮尔曼秩相关分析，RHUI、MHUI、LHUI 和 CHUI 均与 Child-Pugh 和 MELD 评分显著相关（所有 P 值分别为 P = 0.03、P = 0.007 和 P < 0.001，德隆检验）：RHUI有助于定量区分乙肝相关肝硬化的代偿期和失代偿期。

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来源期刊

Canadian Journal of Gastroenterology and Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

37 weeks

期刊介绍： Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.