Modeling brain pathology to study nose-to-brain drug delivery.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2024_67

Аltynay Talgatkyzy, Talgat Khaibullin, Marat Syzdykbayev, Maksut Kazymov, Alua Sharapiyeva, Kuralay Amrenova, Shagiyeva Dinara, Вakytkul Тoktabayeva, Meruyert Khamitova, Bakytbek Apsalikov, Elvira Ozhmukhametova

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Abstract

Objectives: To create a new mucoadhesive dosage form based on PluronicF127 followed by transformation into a gel form upon intranasal administration for targeted delivery to brain tissueMETHODS: Citicoline, cytidine diphosphocholine, designated as CDP-choline, was purchased as a white powder with the molecular weight of 510.31 g/mol. The triblock copolymers of polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol (PEG-PPG-PEG), branded as Pluronic F127, was used.

Results: When instilled into the nasal cavity, Pluronic F127 for intranasal administration is transformed into a gel that remains retained for 45-55 minutes, which promotes better penetration of drugs into the brain tissue.

Conclusion: The polymer's gelling and adhesive properties performed well, which is crucial for further research at the preclinical stage (Tab. 1, Fig. 5, Ref. 28).

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建立脑病理学模型，研究鼻脑给药。

目的以 PluronicF127 为基础创建一种新的粘液粘附剂型，然后在鼻内给药时将其转化为凝胶剂型，以便向脑组织靶向给药。使用聚乙二醇-嵌段-聚丙二醇-嵌段-聚乙二醇（PEG-PPG-PEG）三嵌段共聚物，商标为 Pluronic F127：结果：用于鼻腔内给药的 Pluronic F127 在灌入鼻腔后会转化为凝胶，并在 45-55 分钟内保持不变，从而促进药物更好地渗透到脑组织中：结论：该聚合物的胶凝和粘合性能良好，这对临床前阶段的进一步研究至关重要（表 1，图 5，参考文献 28）。

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来源期刊

Bratislava Medical Journal-Bratislavske Lekarske Listy 医学-医学：内科

CiteScore

2.60

自引率

0.00%

发文量

185

审稿时长

3-8 weeks

期刊介绍： The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.