DNA Methylation of BDNF and RASA2 Genes Is Associated With Cognitive Function in Postmenopausal Women With Breast Cancer.

IF 1.6 4区医学 Q2 NURSING Oncology nursing forum Pub Date : 2024-06-14 DOI:10.1188/24.ONF.349-360

Myeong-Ga Cho, Susan M Sereika, Meredith H Cummings, Kirk I Erickson, Catherine M Bender, Yvette P Conley

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Abstract

Objectives: To determine associations among DNA methylation of brain-derived neurotrophic factor (BDNF) and RAS p21 protein activator 2 (RASA2) genes with processing speed and perceived cognitive function.

Sample & setting: This was a cross-sectional, secondary analysis of baseline data from a randomized controlled trial, the Exercise Program in Cancer and Cognition Study.

Methods & variables: Data included M values for DNA methylation of the BDNF and RASA2 genes; processing speed, objectively measured using the Grooved Pegboard and Digit Vigilance Test scores; and perceived cognitive function, self-reported using the Patient Assessment of Own Functioning Inventory. Regression analysis was conducted.

Results: Greater methylation of cg21291635 of the BDNF gene (p = 0.01) and cg20247102 of the RASA2 gene (p = 0.013) were associated with poorer processing speed, whereas greater methylation of cg20108357 of the BDNF gene (p < 0.001) and cg00567892 of the RASA2 gene (p = 0.019) were associated with better perceived cognitive function.

Implications for nursing: Gene methylation variations were demonstrated, suggesting the genes' potential roles and two possible distinct mechanisms of cognitive function in cancer. .

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BDNF和RASA2基因的DNA甲基化与绝经后乳腺癌妇女的认知功能有关

研究目的确定脑源性神经营养因子（BDNF）和RAS p21蛋白激活剂2（RASA2）基因的DNA甲基化与处理速度和认知功能的关系：这是对一项随机对照试验--"癌症与认知研究中的锻炼计划"--的基线数据进行的横断面二次分析：数据包括：BDNF和RASA2基因DNA甲基化的M值；处理速度（使用凹槽钉板和数字警觉性测试评分进行客观测量）；认知功能（使用患者自身功能评估量表进行自我报告）。结果显示结果：BDNF 基因 cg21291635（p = 0.01）和 RASA2 基因 cg20247102（p = 0.013）的甲基化程度越高，处理速度越差；而 BDNF 基因 cg20108357（p < 0.001）和 RASA2 基因 cg00567892（p = 0.019）的甲基化程度越高，认知功能越好：基因甲基化变异表明了这些基因的潜在作用以及癌症认知功能的两种可能的不同机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology nursing forum 医学-护理

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The mission of the Oncology Nursing Forum, an official publication of ONS, is to Convey research information related to practice, technology, education, and leadership. Disseminate oncology nursing research and evidence-based practice to enhance transdisciplinary quality cancer care. Stimulate discussion of critical issues relevant to oncology nursing.