{"title":"Exploring the landscape of miRNA production and the structural rules that shape it","authors":"","doi":"10.1038/s41477-024-01728-6","DOIUrl":null,"url":null,"abstract":"Degradome sequencing of semi-active DCL1 mutants separates true miRNAs from DCL1-independent small RNAs in Arabidopsis thaliana and illustrates the processing pattern of 147 pri-miRNAs. In parallel, DMS-MaPseq decodes the in vivo secondary structures of pri-miRNAs, enabling a better understanding of cleavage modes and of the impact of DCL1 cofactors on cleavage.","PeriodicalId":18904,"journal":{"name":"Nature Plants","volume":null,"pages":null},"PeriodicalIF":15.8000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Plants","FirstCategoryId":"99","ListUrlMain":"https://www.nature.com/articles/s41477-024-01728-6","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Degradome sequencing of semi-active DCL1 mutants separates true miRNAs from DCL1-independent small RNAs in Arabidopsis thaliana and illustrates the processing pattern of 147 pri-miRNAs. In parallel, DMS-MaPseq decodes the in vivo secondary structures of pri-miRNAs, enabling a better understanding of cleavage modes and of the impact of DCL1 cofactors on cleavage.
期刊介绍：
Nature Plants is an online-only, monthly journal publishing the best research on plants — from their evolution, development, metabolism and environmental interactions to their societal significance.
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