Impact of multidrug resistance on the virulence and fitness of Pseudomonas aeruginosa: a microbiological and clinical perspective.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES Infection Pub Date : 2024-08-01 Epub Date: 2024-07-02 DOI:10.1007/s15010-024-02313-x

Elena Sendra, Almudena Fernández-Muñoz, Laura Zamorano, Antonio Oliver, Juan Pablo Horcajada, Carlos Juan, Silvia Gómez-Zorrilla

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Abstract

Pseudomonas aeruginosa is one of the most common nosocomial pathogens and part of the top emergent species associated with antimicrobial resistance that has become one of the greatest threat to public health in the twenty-first century. This bacterium is provided with a wide set of virulence factors that contribute to pathogenesis in acute and chronic infections. This review aims to summarize the impact of multidrug resistance on the virulence and fitness of P. aeruginosa. Although it is generally assumed that acquisition of resistant determinants is associated with a fitness cost, several studies support that resistance mutations may not be associated with a decrease in virulence and/or that certain compensatory mutations may allow multidrug resistance strains to recover their initial fitness. We discuss the interplay between resistance profiles and virulence from a microbiological perspective but also the clinical consequences in outcomes and the economic impact.

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多重耐药性对铜绿假单胞菌毒力和适应性的影响：微生物学和临床视角。

铜绿假单胞菌是最常见的院内病原体之一，也是与抗菌药耐药性相关的最重要的新出现物种之一，抗菌药耐药性已成为二十一世纪公共卫生的最大威胁之一。这种细菌具有多种毒力因子，有助于急性和慢性感染的发病机制。本综述旨在总结多重耐药性对铜绿假单胞菌毒力和适应性的影响。尽管人们普遍认为耐药性决定因素的获得与体能代价有关，但一些研究支持耐药性突变可能与毒力下降无关，和/或某些补偿性突变可能使耐多药菌株恢复其初始体能。我们不仅从微生物学角度讨论了耐药性特征与毒力之间的相互作用，还讨论了临床结果和经济影响。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.