Cai-Wen Fan, Li Luo, Mei-Shan Li, Yun-Qiong Gu, Yi-Lin Fang, Feng Qin, Heng-Shan Wang
{"title":"Sesquilignans PD from <i>Zanthoxylum nitidum</i> var. <i>tomentosum</i> exerts antitumor effects <i>via</i> the ROS/MAPK pathway in liver cancer cells.","authors":"Cai-Wen Fan, Li Luo, Mei-Shan Li, Yun-Qiong Gu, Yi-Lin Fang, Feng Qin, Heng-Shan Wang","doi":"10.1080/10286020.2024.2371032","DOIUrl":null,"url":null,"abstract":"<p><p>Sesquilignans <b>PD</b> is a natural phenylpropanoid compound that was isolated from <i>Zanthoxylum nitidum</i> var. <i>tomentosum</i>. In this study, we assessed the antitumor effect of <b>PD</b> on SK-Hep-1 and HepG2 cells and the underlying molecular mechanisms. The results revealed that <b>PD</b> markedly inhibited the proliferation and migration of both liver cancer cells. Moreover, <b>PD</b> induced apoptosis, autophagy, and reactive oxygen species (ROS) production in liver cancer cells. Notably, <b>PD</b> increased the protein levels of p-p38 MAPK and p-ERK1/2 in liver cancer cells. This is the first report on the anticancer effect of <b>PD</b>, which is mediated <i>via</i> increased ROS production and MAPK signaling activation.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2024.2371032","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
Sesquilignans PD is a natural phenylpropanoid compound that was isolated from Zanthoxylum nitidum var. tomentosum. In this study, we assessed the antitumor effect of PD on SK-Hep-1 and HepG2 cells and the underlying molecular mechanisms. The results revealed that PD markedly inhibited the proliferation and migration of both liver cancer cells. Moreover, PD induced apoptosis, autophagy, and reactive oxygen species (ROS) production in liver cancer cells. Notably, PD increased the protein levels of p-p38 MAPK and p-ERK1/2 in liver cancer cells. This is the first report on the anticancer effect of PD, which is mediated via increased ROS production and MAPK signaling activation.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
