Age at natural menopause and its associated characteristics among Brazilian women: cross-sectional results from ELSI-Brazil.

IF 2.8 3区医学 Q1 OBSTETRICS & GYNECOLOGY Menopause: The Journal of The North American Menopause Society Pub Date : 2024-08-01 Epub Date: 2024-07-02 DOI:10.1097/GME.0000000000002385

Nair Tavares Milhem Ygnatios, Juliana Vaz de Melo Mambrini, Juliana Lustosa Torres, Larissa Mendes Dias Detomi, Luciana de Souza Braga, Maria Fernanda Lima-Costa, Bruno de Souza Moreira

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Abstract

Objectives: This study aimed to determine the median age at natural menopause and analyze lifestyle, anthropometric, and dietary characteristics associated with the age at natural menopause among Brazilian women.

Methods: This cross-sectional study involved 2,731 women 50 years and over, drawn from the baseline of the Brazilian Longitudinal Study of Aging (ELSI-Brazil, 2015/16). Nonparametric Kaplan-Meier cumulative survivorship estimates were used to assess the median timing of natural menopause. Cox proportional hazards regression models were employed to estimate the associations between age at natural menopause and exposure variables.

Results: The overall median age at natural menopause was 50 years. In the adjusted Cox model, current smoking (hazard ratio [HR], 1.11; 95% CI, 1.01-1.23) and underweight (HR, 1.34; 95% CI, 1.12-1.61) were associated with earlier natural menopause. Conversely, performing recommended levels of physical activity in the last week (HR, 0.88; 95% CI, 0.80-0.97), being overweight (HR 0.86; 95% CI, 0.74-0.99), and adhering to two or three healthy eating markers (HR, 0.80; 95% CI, 0.66-0.97; HR, 0.76; 95% CI, 0.61-0.94, respectively) were associated with later age at natural menopause. Binge drinking and waist circumference were not associated with age at natural menopause.

Conclusions: Lifestyle, anthropometric, and dietary characteristics are significant factors that affect the age at natural menopause. Our findings can contribute to public policies targeted at Brazilian women's health.

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巴西妇女的自然绝经年龄及其相关特征：巴西 ELSI 的横断面结果。

研究目的本研究旨在确定巴西女性自然绝经年龄的中位数，并分析与自然绝经年龄相关的生活方式、人体测量和饮食特征：这项横断面研究涉及巴西老龄化纵向研究（ELSI-Brazil，2015/16 年）基线中的 2731 名 50 岁及以上女性。研究采用非参数卡普兰-梅耶累积存活率估计值来评估自然绝经的中位时间。采用Cox比例危害回归模型来估计自然绝经年龄与暴露变量之间的关联：结果：自然绝经年龄的总体中位数为 50 岁。在调整后的 Cox 模型中，目前吸烟（危险比 [HR]，1.11；95% CI，1.01-1.23）和体重不足（HR，1.34；95% CI，1.12-1.61）与自然绝经时间提前有关。相反，上周进行推荐水平的体育锻炼（HR，0.88；95% CI，0.80-0.97）、超重（HR，0.86；95% CI，0.74-0.99）和坚持两到三个健康饮食指标（HR，0.80；95% CI，0.66-0.97；HR，0.76；95% CI，0.61-0.94）与自然绝经年龄较晚有关。酗酒和腰围与自然绝经年龄无关：结论：生活方式、人体测量和饮食特征是影响自然绝经年龄的重要因素。我们的研究结果有助于制定针对巴西女性健康的公共政策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Menopause: The Journal of The North American Menopause Society 医学-妇产科学

CiteScore

5.40

自引率

7.40%

发文量

330

审稿时长

3-8 weeks

期刊介绍： Menopause, published monthly, provides a forum for new research, applied basic science, and clinical guidelines on all aspects of menopause. The scope and usefulness of the journal extend beyond gynecology, encompassing many varied biomedical areas, including internal medicine, family practice, medical subspecialties such as cardiology and geriatrics, epidemiology, pathology, sociology, psychology, anthropology, and pharmacology. This forum is essential to help integrate these areas, highlight needs for future research, and enhance health care.