G. Z. Raskil’dina, Yu. G. Borisova, A. N. Vereshchagin, E. V. Detusheva, R. M. Sultanova, S. S. Zlotskii
{"title":"Biological Activity of Quaternary Ammonium Salts Containing 1,3-Dioxolane or gem-Dichlorocyclopropane Fragment","authors":"G. Z. Raskil’dina, Yu. G. Borisova, A. N. Vereshchagin, E. V. Detusheva, R. M. Sultanova, S. S. Zlotskii","doi":"10.1134/s2634827624600105","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>Quaternary ammonium salts (QASs) containing <i>gem</i>-dichlorocyclopropane and 1,3-dioxacycloalkane fragments were prepared in 40–90% yields based on pyridine, hexamethylenetetramine, and tertiary amines. The structures of the obtained salts were identified by <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy. The antibacterial activity of QAS against a bacterial strain (<i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>S. aureus</i>, and <i>Acinobacter Baumanii</i>) were assessed<i>.</i> Among the salts tudied, leader compounds were identified that exhibited high antibacterial activity<i>.</i></p>","PeriodicalId":21086,"journal":{"name":"Reviews and Advances in Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews and Advances in Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s2634827624600105","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Quaternary ammonium salts (QASs) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane fragments were prepared in 40–90% yields based on pyridine, hexamethylenetetramine, and tertiary amines. The structures of the obtained salts were identified by 1H and 13C NMR spectroscopy. The antibacterial activity of QAS against a bacterial strain (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinobacter Baumanii) were assessed. Among the salts tudied, leader compounds were identified that exhibited high antibacterial activity.
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