A highly effective method for the environmentally friendly production of novel chromene derivatives using electron deficient compounds

Abstract

New, high-yield derivatives of oxepino[3,2-c]chromene were synthesized through a multicomponent reaction. This reaction involved 2-hydroxyacetophenone, dimethyl carbonate, activated acetylenic compounds, and alkyl bromide. The reaction took place at room temperature in an aqueous environment, resulting in the formation of these innovative compounds. Oxathiepines were synthesized using multicomponent reactions of 2-hydroxyacetophenone, dimethyl carbonate, isothiocyanate, and alkyl bromide in water at room temperature. This technology offers several benefits, including quick response times, high product yields, and easy product separation using straightforward techniques.