Total synthesis of alchivemycin A using a chemoenzymatic strategy

Abstract

Owing to its structural complexity, the total synthesis of alchivemycin A has proved challenging. Now, the total synthesis of alchivemycin A is achieved using a chemoenzymatic approach that combines de novo skeleton construction with a late-stage enzymatic oxidation cascade. Following rational protein engineering of a key enzyme, the final product is obtained in high yield.