Kangbo Li, Mengjun Dai, Mesud Sacirovic, Nikolaos Pagonas, Oliver Ritter, Janine Kah, Martin A Lauxmann, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister
{"title":"Association of endothelial function and lower extremity perfusion in peripheral artery disease.","authors":"Kangbo Li, Mengjun Dai, Mesud Sacirovic, Nikolaos Pagonas, Oliver Ritter, Janine Kah, Martin A Lauxmann, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister","doi":"10.1024/0301-1526/a001131","DOIUrl":null,"url":null,"abstract":"<p><p><b></b> <i>Background:</i> The current study aims to investigate the association between endothelial function and lower extremity perfusion in patients with peripheral artery disease (PAD). <i>Patients and methods</i>: In total 229 patients with PAD (Rutherford stage 0-3) were enrolled in the current study. Endothelial function was assessed by measuring flow-mediated dilation (FMD) and endothelial cell proliferation capacity (ECPC). Lower extremity perfusion was assessed by measuring oscillometry-based ankle brachial index (oABI) and pulse wave index (PWI). In addition, carotid intima-media-thickness (cIMT) was also measured as a surrogate marker for atherosclerosis. Correlations between FMD, ECPC, oABI, PWI, and cIMT were analysed using Pearson correlation coefficient. The relationship between the above variables and the severity of PAD was investigated using ordinal logistic regression analysis. <i>Results</i>: Correlation analysis showed that FMD negatively associated with PWI (r = -0.183, <i>p</i> = 0.005), ECPC positively associated with oABI (r = 0.162, <i>p</i> = 0.014), and oABI negatively associated with PWI (r = -0.264, <i>p</i> < 0.001). Ordinal logistic regression analysis showed that ECPC (<i>β</i> = -0.009, <i>p =</i> 0.048), oABI (<i>β</i> = -5.290, <i>p</i> < 0.001), and age (<i>β</i> = -0.058, <i>p</i> = 0.002) negatively associated with the PAD Rutherford stages. In addition, PWI (<i>β</i> = 0.006, p < 0.001), cIMT (<i>β</i> = 18.363, <i>p =</i> 0.043) positively associated with the PAD Rutherford stages. <i>Conclusions</i>: Endothelial function significantly associates with lower extremity perfusion in patients with PAD, and both are related to the severity of PAD.</p>","PeriodicalId":23528,"journal":{"name":"Vasa-european Journal of Vascular Medicine","volume":" ","pages":"333-340"},"PeriodicalIF":2.1000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vasa-european Journal of Vascular Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1024/0301-1526/a001131","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/9 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The current study aims to investigate the association between endothelial function and lower extremity perfusion in patients with peripheral artery disease (PAD). Patients and methods: In total 229 patients with PAD (Rutherford stage 0-3) were enrolled in the current study. Endothelial function was assessed by measuring flow-mediated dilation (FMD) and endothelial cell proliferation capacity (ECPC). Lower extremity perfusion was assessed by measuring oscillometry-based ankle brachial index (oABI) and pulse wave index (PWI). In addition, carotid intima-media-thickness (cIMT) was also measured as a surrogate marker for atherosclerosis. Correlations between FMD, ECPC, oABI, PWI, and cIMT were analysed using Pearson correlation coefficient. The relationship between the above variables and the severity of PAD was investigated using ordinal logistic regression analysis. Results: Correlation analysis showed that FMD negatively associated with PWI (r = -0.183, p = 0.005), ECPC positively associated with oABI (r = 0.162, p = 0.014), and oABI negatively associated with PWI (r = -0.264, p < 0.001). Ordinal logistic regression analysis showed that ECPC (β = -0.009, p = 0.048), oABI (β = -5.290, p < 0.001), and age (β = -0.058, p = 0.002) negatively associated with the PAD Rutherford stages. In addition, PWI (β = 0.006, p < 0.001), cIMT (β = 18.363, p = 0.043) positively associated with the PAD Rutherford stages. Conclusions: Endothelial function significantly associates with lower extremity perfusion in patients with PAD, and both are related to the severity of PAD.
期刊介绍:
Vasa is the European journal of vascular medicine. It is the official organ of the German, Swiss, and Slovenian Societies of Angiology.
The journal publishes original research articles, case reports and reviews on vascular biology, epidemiology, prevention, diagnosis, medical treatment and interventions for diseases of the arterial circulation, in the field of phlebology and lymphology including the microcirculation, except the cardiac circulation.
Vasa combines basic science with clinical medicine making it relevant to all physicians interested in the whole vascular field.