Association of endothelial function and lower extremity perfusion in peripheral artery disease.

IF 2.1 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE Vasa-european Journal of Vascular Medicine Pub Date : 2024-09-01 Epub Date: 2024-07-09 DOI:10.1024/0301-1526/a001131
Kangbo Li, Mengjun Dai, Mesud Sacirovic, Nikolaos Pagonas, Oliver Ritter, Janine Kah, Martin A Lauxmann, Peter Bramlage, Anja Bondke Persson, Ivo Buschmann, Philipp Hillmeister
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Abstract

Background: The current study aims to investigate the association between endothelial function and lower extremity perfusion in patients with peripheral artery disease (PAD). Patients and methods: In total 229 patients with PAD (Rutherford stage 0-3) were enrolled in the current study. Endothelial function was assessed by measuring flow-mediated dilation (FMD) and endothelial cell proliferation capacity (ECPC). Lower extremity perfusion was assessed by measuring oscillometry-based ankle brachial index (oABI) and pulse wave index (PWI). In addition, carotid intima-media-thickness (cIMT) was also measured as a surrogate marker for atherosclerosis. Correlations between FMD, ECPC, oABI, PWI, and cIMT were analysed using Pearson correlation coefficient. The relationship between the above variables and the severity of PAD was investigated using ordinal logistic regression analysis. Results: Correlation analysis showed that FMD negatively associated with PWI (r = -0.183, p = 0.005), ECPC positively associated with oABI (r = 0.162, p = 0.014), and oABI negatively associated with PWI (r = -0.264, p < 0.001). Ordinal logistic regression analysis showed that ECPC (β = -0.009, p = 0.048), oABI (β = -5.290, p < 0.001), and age (β = -0.058, p = 0.002) negatively associated with the PAD Rutherford stages. In addition, PWI (β = 0.006, p < 0.001), cIMT (β = 18.363, p = 0.043) positively associated with the PAD Rutherford stages. Conclusions: Endothelial function significantly associates with lower extremity perfusion in patients with PAD, and both are related to the severity of PAD.

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外周动脉疾病的内皮功能与下肢灌注的关系。
研究背景本研究旨在探讨外周动脉疾病(PAD)患者的内皮功能与下肢血流灌注之间的关系。患者和方法共有 229 名 PAD 患者(卢瑟福 0-3 期)参加了本次研究。通过测量血流介导的扩张(FMD)和内皮细胞增殖能力(ECPC)来评估内皮功能。下肢血流灌注通过测量基于示波法的踝肱指数(oABI)和脉搏波指数(PWI)进行评估。此外,还测量了颈动脉内膜厚度(cIMT),作为动脉粥样硬化的替代指标。使用皮尔逊相关系数分析了 FMD、ECPC、oABI、PWI 和 cIMT 之间的相关性。使用序数逻辑回归分析研究了上述变量与 PAD 严重程度之间的关系。结果显示相关性分析表明,FMD 与脉搏波速度呈负相关(r = -0.183,p = 0.005),ECPC 与 oABI 呈正相关(r = 0.162,p = 0.014),oABI 与脉搏波速度呈负相关(r = -0.264,p < 0.001)。顺序逻辑回归分析显示,ECPC(β = -0.009,p = 0.048)、oABI(β = -5.290,p <0.001)和年龄(β = -0.058,p = 0.002)与 PAD Rutherford 分期呈负相关。此外,脉搏波速度指数(β = 0.006,p < 0.001)、cIMT(β = 18.363,p = 0.043)与 PAD Rutherford 分期呈正相关。结论内皮功能与 PAD 患者的下肢血流灌注密切相关,两者都与 PAD 的严重程度有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
11.10%
发文量
61
审稿时长
1 months
期刊介绍: Vasa is the European journal of vascular medicine. It is the official organ of the German, Swiss, and Slovenian Societies of Angiology. The journal publishes original research articles, case reports and reviews on vascular biology, epidemiology, prevention, diagnosis, medical treatment and interventions for diseases of the arterial circulation, in the field of phlebology and lymphology including the microcirculation, except the cardiac circulation. Vasa combines basic science with clinical medicine making it relevant to all physicians interested in the whole vascular field.
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