Hai-Lian Yuan, Li Zhang, Wen-Hao Huang, Chang-Gang Sun, Xiao-Dong Luo
{"title":"An updated and comprehensive review of traditional uses, phytochemistry, and pharmacological progress on the Hypecoum genus","authors":"Hai-Lian Yuan, Li Zhang, Wen-Hao Huang, Chang-Gang Sun, Xiao-Dong Luo","doi":"10.1007/s11101-024-09985-1","DOIUrl":null,"url":null,"abstract":"<p>The <i>Hypecoum</i> genus belongs to the family Papaveraceae, consists of roughly 16 accepted species, and is extensively distributed from the Mediterranean to Central Asia and Northern China. It was used widely for the treatment of sore throat, tracheitis, cough, hepatitis, bronchitis, bacterial dysentery, and conjunctive congestion with swelling and pain disease in traditional Chinese and other countries’ medicine, especially in Tibetan or Mongolian medicine. Based on “<i>Hypecoum</i>”, a total of 163 relevant papers published since 1924 were meticulously selected through comprehensive searches of the American Chemical Society (ACS), PubMed, Web of Science, and Science Direct databases. Modern pharmacological researches have evaluated its various biological activities, such as analgesic, anti-inflammatory, antibacterial, hepatoprotective, and antiproliferative activities, even the assessment of its potential for mitigating the impact of corona virus disease 2019 (COVID-19). Approximately 100 alkaloids have been obtained and identified from the <i>Hypecoum</i> species, as well as flavonoid, volatile oil, phenolic, and aromatic compounds. Additionally, the <i>Hypecoum</i> species is widely used in traditional Chinese medicine (TCM) formulae, partial efficacies of which have been verified via numerous pharmacological and clinical investigations, particularly in the treatment of inflammatory and pain diseases. This reviews performed an exhaustive literature review to bridge the knowledge gap that there has yet to be a comprehensive and systematic review addressing the botany, traditional uses, phytochemicals, pharmacological effects, and underlying mechanisms associated with <i>Hypecoum</i> genus. The ultimate aim is to facilitate a solid foundation for the modern research and development of <i>Hypecoum</i> spp., thereby contributing to scientific advancement and enhancing the existing literature in this field.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>","PeriodicalId":733,"journal":{"name":"Phytochemistry Reviews","volume":null,"pages":null},"PeriodicalIF":7.3000,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Reviews","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/s11101-024-09985-1","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
The Hypecoum genus belongs to the family Papaveraceae, consists of roughly 16 accepted species, and is extensively distributed from the Mediterranean to Central Asia and Northern China. It was used widely for the treatment of sore throat, tracheitis, cough, hepatitis, bronchitis, bacterial dysentery, and conjunctive congestion with swelling and pain disease in traditional Chinese and other countries’ medicine, especially in Tibetan or Mongolian medicine. Based on “Hypecoum”, a total of 163 relevant papers published since 1924 were meticulously selected through comprehensive searches of the American Chemical Society (ACS), PubMed, Web of Science, and Science Direct databases. Modern pharmacological researches have evaluated its various biological activities, such as analgesic, anti-inflammatory, antibacterial, hepatoprotective, and antiproliferative activities, even the assessment of its potential for mitigating the impact of corona virus disease 2019 (COVID-19). Approximately 100 alkaloids have been obtained and identified from the Hypecoum species, as well as flavonoid, volatile oil, phenolic, and aromatic compounds. Additionally, the Hypecoum species is widely used in traditional Chinese medicine (TCM) formulae, partial efficacies of which have been verified via numerous pharmacological and clinical investigations, particularly in the treatment of inflammatory and pain diseases. This reviews performed an exhaustive literature review to bridge the knowledge gap that there has yet to be a comprehensive and systematic review addressing the botany, traditional uses, phytochemicals, pharmacological effects, and underlying mechanisms associated with Hypecoum genus. The ultimate aim is to facilitate a solid foundation for the modern research and development of Hypecoum spp., thereby contributing to scientific advancement and enhancing the existing literature in this field.
期刊介绍：
Phytochemistry Reviews is the sole review journal encompassing all facets of phytochemistry. It publishes peer-reviewed papers in six issues annually, including topical issues often stemming from meetings organized by the Phytochemical Society of Europe. Additionally, the journal welcomes original review papers that contribute to advancing knowledge in various aspects of plant chemistry, function, biosynthesis, effects on plant and animal physiology, pathology, and their application in agriculture and industry. Invited meeting papers are supplemented with additional review papers, providing a comprehensive overview of the current status across all areas of phytochemistry.
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