Architecture design and advanced manufacturing of heart-on-a-chip: scaffolds, stimulation and sensors

IF 7.3 1区工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Microsystems & Nanoengineering Pub Date : 2024-07-11 DOI:10.1038/s41378-024-00692-7

Feng Xu, Hang Jin, Lingling Liu, Yuanyuan Yang, Jianzheng Cen, Yaobin Wu, Songyue Chen, Daoheng Sun

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Abstract

Heart-on-a-chip (HoC) has emerged as a highly efficient, cost-effective device for the development of engineered cardiac tissue, facilitating high-throughput testing in drug development and clinical treatment. HoC is primarily used to create a biomimetic microphysiological environment conducive to fostering the maturation of cardiac tissue and to gather information regarding the real-time condition of cardiac tissue. The development of architectural design and advanced manufacturing for these “3S” components, scaffolds, stimulation, and sensors is essential for improving the maturity of cardiac tissue cultivated on-chip, as well as the precision and accuracy of tissue states. In this review, the typical structures and manufacturing technologies of the “3S” components are summarized. The design and manufacturing suggestions for each component are proposed. Furthermore, key challenges and future perspectives of HoC platforms with integrated “3S” components are discussed.

Architecture design concepts of scaffolds, stimulation and sensors in chips.

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芯片心脏的结构设计和先进制造：支架、刺激和传感器

芯片上心脏（HoC）是一种高效、经济的设备，可用于开发工程心脏组织，促进药物开发和临床治疗中的高通量测试。片上心脏主要用于创建有利于促进心脏组织成熟的仿生微生理环境，并收集有关心脏组织实时状况的信息。为这些 "3S "组件、支架、刺激和传感器开发结构设计和先进制造技术，对于提高芯片上培养的心脏组织的成熟度以及组织状态的精度和准确性至关重要。本综述总结了 "3S "组件的典型结构和制造技术。提出了各组件的设计和制造建议。此外，还讨论了集成 "3S "组件的心血管系统平台所面临的主要挑战和未来展望。

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来源期刊

Microsystems & Nanoengineering Materials Science-Materials Science (miscellaneous)

CiteScore

12.00

自引率

3.80%

发文量

123

审稿时长

20 weeks

期刊介绍： Microsystems & Nanoengineering is a comprehensive online journal that focuses on the field of Micro and Nano Electro Mechanical Systems (MEMS and NEMS). It provides a platform for researchers to share their original research findings and review articles in this area. The journal covers a wide range of topics, from fundamental research to practical applications. Published by Springer Nature, in collaboration with the Aerospace Information Research Institute, Chinese Academy of Sciences, and with the support of the State Key Laboratory of Transducer Technology, it is an esteemed publication in the field. As an open access journal, it offers free access to its content, allowing readers from around the world to benefit from the latest developments in MEMS and NEMS.