Effect of Royal Sun Medicinal Mushroom Agaricus brasiliensis KA21 (Agaricomycetes) Cultivated Outdoors on Wound Healing and Maintaining Skin Elasticity

IF 1.4 4区生物学 Q4 MYCOLOGY International journal of medicinal mushrooms Pub Date : 2024-07-01 DOI:10.1615/intjmedmushrooms.2024054886

Akitomo Motoi, Katsuya Tajima, Rina Motoi, Masuro Motoi, Hoichi Amano, Daisuke Yamanaka, Ken-ichi Ishibashi, Naohito Ohno, Yoshiyuki Adachi

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Abstract

Royal sun medicinal mushroom Agaricus brasiliensis KA21 has various beneficial pharmacological effects; however, these effects are influenced by its cultivation conditions. A. brasiliensis KA21 is rich in β-glucan, which promotes wound healing. This study evaluated the wound healing-promoting effects of A. brasiliensis KA21 and the influence of cultivation conditions on these effects. Upon evaluation of its effect on wound healing, the outdoor-cultivated A. brasiliensis KA21 (KAOD) promoted wound healing in mice, and the effect of KAOD was stronger than that of the indoor-cultivated one (KAID). In addition, A. brasiliensis KA21 promoted the synthesis of collagen I and III, which are involved in promoting wound healing; KAOD strongly induced collagen III production. Furthermore, KAOD suppressed the decrease in skin elasticity after acetone application in our mouse model, which was not observed for KAID. These results show that KAOD is useful as a supplement in surgery and injury healing for humans and animals, improving immunity against pathogens in wound areas and promoting wound healing. In addition, KAOD may be useful in the field of skin aesthetics for repairing skin damage and maintaining skin elasticity.

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室外栽培的皇家太阳药用蘑菇 Agaricus brasiliensis KA21（姬松茸）对伤口愈合和保持皮肤弹性的影响

皇家太阳药用蘑菇巴西蘑菇（Agaricus brasiliensis KA21）具有多种有益的药理作用，但这些作用受其栽培条件的影响。巴西蘑菇 KA21 富含能促进伤口愈合的 β-葡聚糖。本研究评估了 A. brasiliensis KA21 促进伤口愈合的作用以及栽培条件对这些作用的影响。在评估其对伤口愈合的影响时，室外栽培的巴西蘑菇 A. brasiliensis KA21（KAOD）能促进小鼠伤口愈合，且 KAOD 的效果强于室内栽培的 A. brasiliensis KA21（KAID）。此外，A. brasiliensis KA21 能促进胶原蛋白 I 和 III 的合成，而胶原蛋白 I 和 III 参与促进伤口愈合；KAOD 能强烈诱导胶原蛋白 III 的生成。此外，在我们的小鼠模型中，KAOD 还能抑制应用丙酮后皮肤弹性的降低，而 KAID 则没有这种效果。这些结果表明，KAOD 可作为人类和动物手术和损伤愈合的补充剂，提高伤口部位对病原体的免疫力，促进伤口愈合。此外，KAOD 还可用于皮肤美容领域，修复皮肤损伤，保持皮肤弹性。

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来源期刊

International journal of medicinal mushrooms 医学-药学

CiteScore

2.60

自引率

16.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.