The function of long non-coding RNA IFNG-AS1 in autoimmune diseases.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-09-01 Epub Date: 2024-07-14 DOI:10.1007/s13577-024-01103-9

Jiale Zhao, Yibei Gui, Wei Wu, Xueqing Li, Lijun Wang, Hailin Wang, Yiyang Luo, Gang Zhou, Chengfu Yuan

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Abstract

The prevalence of autoimmune diseases ranks as the third most common disease category globally, following cancer and heart disease. Numerous studies indicate that long non-coding RNA (lncRNA) plays a pivotal role in regulating human growth, development, and the pathogenesis of various diseases. It is more than 200 nucleotides in length and is mostly involve in the regulation of gene expression. Furthermore, lncRNAs are crucial in the development and activation of immune cells, with an expanding body of research exploring their association with autoimmune disorders in humans. LncRNA Ifng antisense RNA 1 (IFNG-AS1), a key regulatory factor in the immune system, also named NeST or TMEVPG1, is proximally located to IFNG and participates in the regulation of it. The dysregulation of IFNG-AS1 is implicated in the pathogenesis of several autoimmune diseases. This study examines the role and mechanism of IFNG-AS1 in various autoimmune diseases and considers its potential as a therapeutic target.

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长非编码 RNA IFNG-AS1 在自身免疫性疾病中的功能

自身免疫性疾病是继癌症和心脏病之后全球第三大常见疾病。大量研究表明，长非编码 RNA（lncRNA）在调节人类生长、发育和各种疾病的发病机制方面发挥着关键作用。它的长度超过 200 个核苷酸，主要参与基因表达的调控。此外，lncRNA 在免疫细胞的发育和激活过程中起着至关重要的作用，越来越多的研究正在探索它们与人类自身免疫性疾病的关系。LncRNA Ifng antisense RNA 1（IFNG-AS1）是免疫系统中的一个关键调控因子，也被命名为 NeST 或 TMEVPG1，它与 IFNG 位于近端，参与对 IFNG 的调控。IFNG-AS1 的失调与多种自身免疫性疾病的发病机制有关。本研究探讨了 IFNG-AS1 在多种自身免疫性疾病中的作用和机制，并考虑了其作为治疗靶点的潜力。

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