Feasibility study to unveil the potential: considerations of constrained spherical deconvolution tractography with unsedated neonatal diffusion brain MRI data.

Frontiers in radiology Pub Date : 2024-06-28 eCollection Date: 2024-01-01 DOI:10.3389/fradi.2024.1416672
Anouk S Verschuur, Chantal M W Tax, Martijn F Boomsma, Helen L Carlson, Gerda van Wezel-Meijler, Regan King, Alexander Leemans, Lara M Leijser
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Abstract

Purpose: The study aimed to (1) assess the feasibility constrained spherical deconvolution (CSD) tractography to reconstruct crossing fiber bundles with unsedated neonatal diffusion MRI (dMRI), and (2) demonstrate the impact of spatial and angular resolution and processing settings on tractography and derived quantitative measures.

Methods: For the purpose of this study, the term-equivalent dMRIs (single-shell b800, and b2000, both 5 b0, and 45 gradient directions) of two moderate-late preterm infants (with and without motion artifacts) from a local cohort [Brain Imaging in Moderate-late Preterm infants (BIMP) study; Calgary, Canada] and one infant from the developing human connectome project with high-quality dMRI (using the b2600 shell, comprising 20 b0 and 128 gradient directions, from the multi-shell dataset) were selected. Diffusion tensor imaging (DTI) and CSD tractography were compared on b800 and b2000 dMRI. Varying image resolution modifications, (pre-)processing and tractography settings were tested to assess their impact on tractography. Each experiment involved visualizing local modeling and tractography for the corpus callosum and corticospinal tracts, and assessment of morphological and diffusion measures.

Results: Contrary to DTI, CSD enabled reconstruction of crossing fibers. Tractography was susceptible to image resolution, (pre-) processing and tractography settings. In addition to visual variations, settings were found to affect streamline count, length, and diffusion measures (fractional anisotropy and mean diffusivity). Diffusion measures exhibited variations of up to 23%.

Conclusion: Reconstruction of crossing fiber bundles using CSD tractography with unsedated neonatal dMRI data is feasible. Tractography settings affected streamline reconstruction, warranting careful documentation of methods for reproducibility and comparison of cohorts.

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揭示潜能的可行性研究:利用未定时新生儿脑部弥散磁共振成像数据进行受限球形去卷积牵引成像的考虑。
目的:该研究旨在(1)评估利用非静息新生儿弥散核磁共振成像(dMRI)重建交叉纤维束的受限球形去卷积(CSD)束成像的可行性;(2)证明空间和角度分辨率以及处理设置对束成像和衍生定量测量的影响:为本研究的目的,对来自本地队列[中晚期早产儿脑成像(BIMP)研究,加拿大卡尔加里]的两名中晚期早产儿(有运动伪影和无运动伪影)和一名中晚期早产儿的术语等效 dMRI(单壳 b800 和 b2000,均为 5 b0,45 梯度方向)进行了研究;BIMP 研究;加拿大卡尔加里]中的一个早产儿(有运动伪影和无运动伪影),以及 "发展中人类连接体项目 "中的一个婴儿(使用多外壳数据集中的 b2600 外壳,包括 20 个 b0 和 128 个梯度方向)。在 b800 和 b2000 dMRI 上比较了弥散张量成像(DTI)和 CSD 牵引成像。测试了不同的图像分辨率修改、(预)处理和牵引成像设置,以评估它们对牵引成像的影响。每项实验都包括对胼胝体和皮质脊髓束的局部建模和牵引成像进行可视化,以及对形态学和弥散测量进行评估:结果:与 DTI 相反,CSD 能够重建交叉纤维。牵引成像易受图像分辨率、(预)处理和牵引成像设置的影响。除视觉变化外,设置也会影响流线数、长度和扩散测量(分数各向异性和平均扩散率)。扩散测量值的变化高达 23%:结论:利用CSD束描技术和非静息新生儿dMRI数据重建交叉纤维束是可行的。牵引成像的设置会影响重建的流线型,因此需要仔细记录重建方法的可重复性和队列比较。
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