Biomarkers in Psoriasis and Psoriatic Arthritis: Where Are We Now?

IF 3.6 2区 医学 Q2 RHEUMATOLOGY Journal of Rheumatology Pub Date : 2024-10-01 DOI:10.3899/jrheum.2024-0260
Vinod Chandran, Wilson Liao, Kurt de Vlam
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Abstract

At the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2023 annual conference and trainee symposium, the status of psoriatic disease (PsD) biomarkers was discussed in a workshop. The significant heterogeneity of PsD causes disease management to be very challenging, but biomarkers can prove helpful in disease diagnosis, stratification, and precision medicine. Although a few potential biomarkers have been discovered, none have been fully validated. Recent studies have used omic technologies that show promise but need further verification and validation. Many challenges remain, but the anticipated results of studies being conducted by recently established large consortia may lead to the identification of clinically actionable biomarkers.

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银屑病和银屑病关节炎的生物标记物:我们现在在哪里?
在银屑病和银屑病关节炎研究与评估小组(GRAPPA)2023年年会暨学员研讨会上,与会者在一次研讨会上讨论了银屑病(PsD)生物标志物的现状。银屑病具有明显的异质性,因此疾病管理非常具有挑战性,但生物标志物有助于疾病诊断、分层和精准医疗。虽然已经发现了一些潜在的生物标志物,但还没有一个得到充分验证。最近的研究已经使用了显示前景的 omic 技术,但还需要进一步的验证和确认。许多挑战依然存在,但最近成立的大型联盟正在进行的研究的预期结果可能会导致临床可操作生物标志物的确定。
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来源期刊
Journal of Rheumatology
Journal of Rheumatology 医学-风湿病学
CiteScore
6.50
自引率
5.10%
发文量
285
审稿时长
1 months
期刊介绍: The Journal of Rheumatology is a monthly international serial edited by Earl D. Silverman. The Journal features research articles on clinical subjects from scientists working in rheumatology and related fields, as well as proceedings of meetings as supplements to regular issues. Highlights of our 41 years serving Rheumatology include: groundbreaking and provocative editorials such as "Inverting the Pyramid," renowned Pediatric Rheumatology, proceedings of OMERACT and the Canadian Rheumatology Association, Cochrane Musculoskeletal Reviews, and supplements on emerging therapies.
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