mRNA-based HIV-1 vaccines.

IF 19 1区 医学 Q1 MICROBIOLOGY Clinical Microbiology Reviews Pub Date : 2024-09-12 Epub Date: 2024-07-17 DOI:10.1128/cmr.00041-24
Shamim Ahmed, Alon Herschhorn
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Abstract

SUMMARYThe success of the Severe Acute Respiratory Syndrome Coronavirus 2 mRNA vaccines to lessen/prevent severe COVID-19 opened new opportunities to develop RNA vaccines to fight other infectious agents. HIV-1 is a lentivirus that integrates into the host cell genome and persists for the lifetime of infected cells. Multiple mechanisms of immune evasion have posed significant obstacles to the development of an effective HIV-1 vaccine over the last four decades since the identification of HIV-1. Recently, attempts to address some of these challenges have led to multiple studies that manufactured, optimized, and tested, in different animal models, mRNA-based HIV-1 vaccines. Several clinical trials have also been initiated or are planned to start soon. Here, we review the current strategies applied to HIV-1 mRNA vaccines, discuss different targeting approaches, summarize the latest findings, and offer insights into the challenges and future of HIV-1 mRNA vaccines.

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基于 mRNA 的 HIV-1 疫苗。
摘要 严重急性呼吸系统综合征冠状病毒 2 mRNA 疫苗在减轻/预防严重 COVID-19 方面取得了成功,这为开发 RNA 疫苗以对抗其他传染病病原体提供了新的机遇。HIV-1 是一种慢病毒,可整合到宿主细胞基因组中,并在受感染细胞的整个生命周期中持续存在。自发现 HIV-1 以来的 40 年中,多种免疫逃避机制对开发有效的 HIV-1 疫苗构成了重大障碍。最近,为了应对其中的一些挑战,人们开展了多项研究,制造、优化并在不同动物模型中测试基于 mRNA 的 HIV-1 疫苗。一些临床试验也已经启动或计划很快启动。在此,我们回顾了目前应用于 HIV-1 mRNA 疫苗的策略,讨论了不同的靶向方法,总结了最新发现,并对 HIV-1 mRNA 疫苗面临的挑战和未来提出了见解。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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