Exploring treatment options in cancer: Tumor treatment strategies.

IF 40.8 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Signal Transduction and Targeted Therapy Pub Date : 2024-07-17 DOI:10.1038/s41392-024-01856-7
Beilei Liu, Hongyu Zhou, Licheng Tan, Kin To Hugo Siu, Xin-Yuan Guan
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Abstract

Traditional therapeutic approaches such as chemotherapy and radiation therapy have burdened cancer patients with onerous physical and psychological challenges. Encouragingly, the landscape of tumor treatment has undergone a comprehensive and remarkable transformation. Emerging as fervently pursued modalities are small molecule targeted agents, antibody-drug conjugates (ADCs), cell-based therapies, and gene therapy. These cutting-edge treatment modalities not only afford personalized and precise tumor targeting, but also provide patients with enhanced therapeutic comfort and the potential to impede disease progression. Nonetheless, it is acknowledged that these therapeutic strategies still harbour untapped potential for further advancement. Gaining a comprehensive understanding of the merits and limitations of these treatment modalities holds the promise of offering novel perspectives for clinical practice and foundational research endeavours. In this review, we discussed the different treatment modalities, including small molecule targeted drugs, peptide drugs, antibody drugs, cell therapy, and gene therapy. It will provide a detailed explanation of each method, addressing their status of development, clinical challenges, and potential solutions. The aim is to assist clinicians and researchers in gaining a deeper understanding of these diverse treatment options, enabling them to carry out effective treatment and advance their research more efficiently.

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探索癌症治疗方案:肿瘤治疗策略。
化疗和放疗等传统治疗方法给癌症患者带来了沉重的生理和心理负担。令人鼓舞的是,肿瘤治疗的格局已经发生了全面而显著的转变。小分子靶向药物、抗体药物共轭物(ADC)、细胞疗法和基因疗法成为人们热衷追求的治疗方式。这些前沿治疗模式不仅能实现个性化和精确的肿瘤靶向治疗,还能为患者提供更舒适的治疗环境,并有可能阻碍疾病的进展。尽管如此,这些治疗策略仍然蕴藏着有待进一步开发的潜力。全面了解这些治疗方法的优点和局限性,有望为临床实践和基础研究工作提供新的视角。在这篇综述中,我们讨论了不同的治疗模式,包括小分子靶向药物、多肽药物、抗体药物、细胞疗法和基因疗法。它将对每种方法进行详细说明,探讨其发展现状、临床挑战和潜在的解决方案。目的是帮助临床医生和研究人员更深入地了解这些不同的治疗方案,使他们能够更有效地开展治疗和推进研究。
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来源期刊
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
44.50
自引率
1.50%
发文量
384
审稿时长
5 weeks
期刊介绍: Signal Transduction and Targeted Therapy is an open access journal that focuses on timely publication of cutting-edge discoveries and advancements in basic science and clinical research related to signal transduction and targeted therapy. Scope: The journal covers research on major human diseases, including, but not limited to: Cancer,Cardiovascular diseases,Autoimmune diseases,Nervous system diseases.
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