Bone Cement in Adult Hip and Knee Reconstruction: A Review of Commercially Available Options and Clinical Outcomes.

IF 2.6 2区 医学 Q1 ORTHOPEDICS Journal of the American Academy of Orthopaedic Surgeons Pub Date : 2024-10-15 Epub Date: 2024-07-16 DOI:10.5435/JAAOS-D-23-01232
Richard Auran, Kamran Movassaghi, Denis Nam, Nathanael Heckmann
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Abstract

Polymethyl-methacrylate (PMMA) bone cement is used extensively in hip and knee arthroplasty. A thorough understanding of the basic chemistry underlying PMMA is important for orthopaedic surgeons because this underscores the specific way bone cement is used during surgery. Recently, clinical research has shed light on the various types of PMMA regarding the viscosity of the mixture and the effect of cement additives. These variations in composition may alter the clinical efficacy of implanted bone cement in hip and knee arthroplasty. Understanding these key differences will allow the surgeon to tailor the PMMA composition as needed to maximize outcomes of hip and knee arthroplasty. This review will summarize the preclinical feature of PMMA, evaluate current and past commercially available bone cement options, analyze preclinical results and clinical outcomes of various bone cement types, and highlight future areas of research.

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成人髋关节和膝关节重建中的骨水泥:市售选择和临床结果综述
聚甲基丙烯酸甲酯(PMMA)骨水泥广泛用于髋关节和膝关节置换术。透彻了解PMMA的基本化学成分对整形外科医生来说非常重要,因为这强调了骨水泥在手术中的具体使用方法。最近,临床研究揭示了各种类型 PMMA 的混合物粘度和骨水泥添加剂的影响。这些成分上的差异可能会改变植入骨水泥在髋关节和膝关节置换术中的临床疗效。了解这些关键差异将使外科医生能够根据需要调整 PMMA 成分,以最大限度地提高髋关节和膝关节置换术的效果。本综述将总结 PMMA 的临床前特征,评估当前和过去的商用骨水泥选择,分析各种骨水泥类型的临床前结果和临床疗效,并强调未来的研究领域。
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来源期刊
CiteScore
6.10
自引率
6.20%
发文量
529
审稿时长
4-8 weeks
期刊介绍: The Journal of the American Academy of Orthopaedic Surgeons was established in the fall of 1993 by the Academy in response to its membership’s demand for a clinical review journal. Two issues were published the first year, followed by six issues yearly from 1994 through 2004. In September 2005, JAAOS began publishing monthly issues. Each issue includes richly illustrated peer-reviewed articles focused on clinical diagnosis and management. Special features in each issue provide commentary on developments in pharmacotherapeutics, materials and techniques, and computer applications.
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