Platelet transfusion prior to major surgery in a thrombocytopenic dog

Abstract

Fresh platelet concentrate (FPC) is described as the product of choice for the control of bleeding due to severe thrombocytopenia and has recently become commercially available in the UK. We report a successful, prophylactic FPC transfusion when given in combination with tranexamic acid prior to fracture repair in a 4‐year‐old Whippet. The patient presented with right radial and ulnar fractures and severe thrombocytopenia (platelet count 23 × 109/L). Viscoelastic coagulation monitoring (VCM) revealed coagulopathy, with prolonged clot formation times, but other coagulation parameters were within normal limits. One unit (65 mL) of FPC was given pre‐operatively. The dog underwent surgery without excessive bleeding and experienced no complications. Post‐transfusion VCM showed improved clot formation and clot strength. Transfusion of FPC in combination with tranexamic acid increased this dog's ability to clot, suggesting that it is an effective perioperative therapy for severely thrombocytopenic patients requiring urgent surgery.