ALT in Preeclampsia

Delta Medical College Journal Pub Date : 2024-07-14 DOI:10.3329/dmcj.v9i2.74867

Razia Sultana, Selina Ahmed, Nasima Sultana, F. Diba

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Abstract

Background: Preeclampsia is the most frequent cause of abnormal liver function test in pregnancy. Women with preeclampsia and raised serum alanine aminotransferase (ALT) have chance of greater proteinuria and more maternal complications than those with normal liver function. Objective: The present study was designed to assess the association of serum ALT with preeclampsia. Materials and method: A case control study was conducted in the Department of Biochemistry, Dhaka Medical College,Dhaka, Bangladesh, from July 2010 to June 2011. From the pregnant women in third trimester of pregnancy attending in Obstetrics and Gynecology Department of Dhaka Medical College Hospital, 50 diagnosed cases of preeclampsia were selected purposively as cases and 50 normal healthy pregnant women as controls. Serum ALT concentration was measured in all the study subjects. Results: The mean serum ALT concentration in cases and controls were 57.92±20.99 U/L and 15.46±2.66 U/L respectively. The level was significantly higher in cases than that of controls (p=0.001). Conclusion: The study revealed that increased serum ALT concentration is associated with preeclampsia. Delta Med Col J. Jan 2021;9(2): 65-68

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子痫前期的谷丙转氨酶

背景：子痫前期是导致妊娠期肝功能检测异常的最常见原因。与肝功能正常的妇女相比，患有子痫前期且血清丙氨酸氨基转移酶（ALT）升高的妇女有可能出现更多的蛋白尿和更多的孕产并发症：本研究旨在评估血清 ALT 与子痫前期的关系。材料和方法：2010 年 7 月至 2011 年 6 月，孟加拉国达卡医学院生物化学系开展了一项病例对照研究。从达卡医学院附属医院妇产科就诊的怀孕三个月的孕妇中，有目的性地选择 50 例确诊为子痫前期的孕妇作为病例，50 例正常健康孕妇作为对照。对所有研究对象的血清 ALT 浓度进行了测量：结果：病例和对照组的平均血清 ALT 浓度分别为 57.92±20.99 U/L和 15.46±2.66 U/L。病例的水平明显高于对照组（P=0.001）：研究显示，血清ALT浓度升高与子痫前期有关。Delta Med Col J. Jan 2021;9(2)：65-68

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Delta Medical College Journal

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20 weeks