The modulatory effects of tyrosol and nano-tyrosol on anxiety-like behavior and emotional memory in streptozotocin-induced diabetic rats

IF 1.6 4区医学 Q4 NEUROSCIENCES Neuroreport Pub Date : 2024-07-10 DOI:10.1097/wnr.0000000000002061

Maryam Naseroleslami, Fatemeh Khakpai, Nima Jafari-Rastegar, H. Hosseininia, Elahe Jalilvand, Neda Mousavi-Niri

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Abstract

The effects of tyrosol and nano-tyrosol on the modulation of anxiety-like behavior and memory processes were evaluated in streptozotocin-induced diabetic rats. Male diabetic rats were orally treated with 1 ml of saline, nano-niosome, tyrosol, and nano-tyrosol (20 mg/dl) for 30 days. Anxiety-like behavior and memory process were evaluated by an elevated plus-maze (EPM) test–retest paradigm. The results showed that a single intraperitoneal (i.p.) administration of streptozotocin (50 mg/kg) raised blood glucose. While daily intragastric administration of tyrosol and nano-tyrosol reduced blood glucose. Induction of type II diabetes produced a distorted cellular arrangement whereas treatment with tyrosol and nano-tyrosol showed a typical cellular arrangement in the liver. Furthermore, induction of type II diabetes decreased %OAT (%open-arm time) but daily intragastric application of tyrosol (20 mg/dl) and nano-tyrosol (20 mg/dl) enhanced %OAT and %OAE (%open-arm entry) in the EPM when compared to the saline groups, showing anxiogenic- and anxiolytic-like effects, respectively. Also, induction of type II diabetes increased %OAT while daily intragastric administration of tyrosol (20 mg/dl) and nano-tyrosol (20 mg/dl) decreased %OAT and %OAE in the EPM in comparison to the saline groups, displaying impairment and improvement of emotional memory, respectively. Interestingly, nano-tyrosol exhibited the highest significant effect rather than tyrosol. Upon these results, we proposed the beneficial effects of tyrosol and nano-tyrosol on the modulation of anxiety-like behavior and memory processes in streptozotocin-induced diabetic rats.

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酪醇和纳米酪醇对链脲佐菌素诱导的糖尿病大鼠焦虑样行为和情绪记忆的调节作用

研究评估了酪醇和纳米酪醇对链脲佐菌素诱导的糖尿病大鼠焦虑样行为和记忆过程的调节作用。雄性糖尿病大鼠口服 1 毫升生理盐水、纳米酪醇、酪醇和纳米酪醇（20 毫克/分升），连续 30 天。焦虑样行为和记忆过程通过高架迷宫（EPM）测试-重复范式进行评估。结果显示，单次腹腔注射链脲佐菌素（50 毫克/千克）会升高血糖。而每日胃内注射酪醇和纳米酪醇可降低血糖。诱导 II 型糖尿病会产生扭曲的细胞排列，而用酪醇和纳米酪醇处理则会在肝脏中显示出典型的细胞排列。此外，诱导II型糖尿病会降低开臂时间%OAT，但与生理盐水组相比，每天胃内注射酪醇（20毫克/分升）和纳米酪醇（20毫克/分升）会提高EPM的开臂时间%OAT和开臂时间%OAE，分别显示出致焦虑和抗焦虑作用。此外，诱导II型糖尿病会增加OAT%，而与生理盐水组相比，每日胃内注射酪醇（20毫克/分升）和纳米酪醇（20毫克/分升）会降低EPM的OAT%和OAE%，分别显示出情绪记忆的损害和改善。有趣的是，与酪醇相比，纳米酪醇的效果最为显著。根据这些结果，我们提出了酪醇和纳米酪醇对链脲佐菌素诱导的糖尿病大鼠焦虑样行为和记忆过程的调节作用。

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.