A Review On : To Develop and Validate Analytical Method for Determination of Methimazole in Bulk and Pharmaceutical Dosage Form

Akankshsa S. Atole, Payal S. Badhe, Vijaya U. Barge
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Abstract

Hyperthyroidism is a condition characterized by increased in synthesis and secretion of thyroid hormones from thyroid gland. Methimazole is an anti-hyperthyroidism drug. It is of great importance and significance for life science. Up to now, various different methods have been applied for the determination of methimazole, such as spectrophotometry1-3, LC4, HPLC6, RP-HPLC7, HPLC-UV8, electrochemical analysis9, kinetic method10. In this paper, a new UV-Spectrophotometric method for the determination of methimazole has been established. The chemical name of Methimazole is (1-methylimidazole-2-thiol). The chemical formula of Methimazole is C4H6N2S and the molecular weight is 114.17 g/mol. The structure of Methimazole features a 5 membered imidazole ring with a methyl group at position 1st and thione group at position 2nd. Methimazole is white colour powder and has melting point 1440 C.
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综述:开发并验证测定散装和药物剂型中甲亢唑的分析方法
甲状腺功能亢进症是一种以甲状腺合成和分泌甲状腺激素增加为特征的疾病。甲巯咪唑是一种抗甲亢药物。它对生命科学具有重要意义。迄今为止,已有多种不同的方法用于甲巯咪唑的测定,如分光光度法1-3、LC4、HPLC6、RP-HPLC7、HPLC-UV8、电化学分析法9、动力学法10等。本文建立了一种新的紫外分光光度法测定甲巯咪唑。甲巯咪唑的化学名称是(1-甲基咪唑-2-硫醇)。甲巯咪唑的化学式为 C4H6N2S,分子量为 114.17 g/mol。甲巯咪唑的结构是一个 5 位咪唑环,第 1 位是甲基,第 2 位是硫酮基团。甲巯咪唑为白色粉末,熔点为 1440 摄氏度。
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