A Review On : To Develop and Validate Analytical Method for Determination of Methimazole in Bulk and Pharmaceutical Dosage Form

Akankshsa S. Atole, Payal S. Badhe, Vijaya U. Barge
{"title":"A Review On : To Develop and Validate Analytical Method for Determination of Methimazole in Bulk and Pharmaceutical Dosage Form","authors":"Akankshsa S. Atole, Payal S. Badhe, Vijaya U. Barge","doi":"10.32628/ijsrst24113248","DOIUrl":null,"url":null,"abstract":"Hyperthyroidism is a condition characterized by increased in synthesis and secretion of thyroid hormones from thyroid gland. Methimazole is an anti-hyperthyroidism drug. It is of great importance and significance for life science. Up to now, various different methods have been applied for the determination of methimazole, such as spectrophotometry1-3, LC4, HPLC6, RP-HPLC7, HPLC-UV8, electrochemical analysis9, kinetic method10. In this paper, a new UV-Spectrophotometric method for the determination of methimazole has been established. The chemical name of Methimazole is (1-methylimidazole-2-thiol). The chemical formula of Methimazole is C4H6N2S and the molecular weight is 114.17 g/mol. The structure of Methimazole features a 5 membered imidazole ring with a methyl group at position 1st and thione group at position 2nd. Methimazole is white colour powder and has melting point 1440 C.","PeriodicalId":14387,"journal":{"name":"International Journal of Scientific Research in Science and Technology","volume":" 17","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Scientific Research in Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32628/ijsrst24113248","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Hyperthyroidism is a condition characterized by increased in synthesis and secretion of thyroid hormones from thyroid gland. Methimazole is an anti-hyperthyroidism drug. It is of great importance and significance for life science. Up to now, various different methods have been applied for the determination of methimazole, such as spectrophotometry1-3, LC4, HPLC6, RP-HPLC7, HPLC-UV8, electrochemical analysis9, kinetic method10. In this paper, a new UV-Spectrophotometric method for the determination of methimazole has been established. The chemical name of Methimazole is (1-methylimidazole-2-thiol). The chemical formula of Methimazole is C4H6N2S and the molecular weight is 114.17 g/mol. The structure of Methimazole features a 5 membered imidazole ring with a methyl group at position 1st and thione group at position 2nd. Methimazole is white colour powder and has melting point 1440 C.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
综述:开发并验证测定散装和药物剂型中甲亢唑的分析方法
甲状腺功能亢进症是一种以甲状腺合成和分泌甲状腺激素增加为特征的疾病。甲巯咪唑是一种抗甲亢药物。它对生命科学具有重要意义。迄今为止,已有多种不同的方法用于甲巯咪唑的测定,如分光光度法1-3、LC4、HPLC6、RP-HPLC7、HPLC-UV8、电化学分析法9、动力学法10等。本文建立了一种新的紫外分光光度法测定甲巯咪唑。甲巯咪唑的化学名称是(1-甲基咪唑-2-硫醇)。甲巯咪唑的化学式为 C4H6N2S,分子量为 114.17 g/mol。甲巯咪唑的结构是一个 5 位咪唑环,第 1 位是甲基,第 2 位是硫酮基团。甲巯咪唑为白色粉末,熔点为 1440 摄氏度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Analysis of Radiation Dose Rate and Evaluation of Whole Body Scan SPECT/CT Images in Thyroid Carcinoma Radioablation Patients Using Radioisotope 131I Biodistribution and Absorption of Radiopharmaceutical 99mTc MDP in Various Bones of Lung Cancer Patients Using SPECT/CT Modalities Study of Intermolecular Interaction by Ultrasonic Measurements of 1-Butanol-Pyridine and Toluene-Pyridine at 303.15 To 323.15 K and Statistical Analysis of Liquid State Theories Review about Organic-Inorganic Perovskite Single Crystal : Synthesis Methods, Properties and Applications Machine Learning Based Liver Cirrhosis Detection Using Different Algorithm : A Review
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1