Aberrant Immunohistochemical Expression of P53 in Ameloblastoma, Ameloblastic Carcinoma, Dentigerous Cyst and Odontogenic Keratocyst: A comparative Study

Abstract

Background: odontogenic lesions comprise a diverse group exhibiting a wide range of clinical and biological behaviors, demanding a meticulous understanding for accurate diagnosis and management. In response to DNA damage, the p53 tumor suppressor protein functions as a key regulator, inducing either cell cycle arrest or apoptosis. Mutations in the p53 gene are frequently observed in human cancers; however, the role of p53 expression in odontogenic lesions remains unclear. Material and methods: A retrospective design was employed to evaluate and compare p53 protein expression patterns, detected by immunohistochemistry, in ameloblastoma, ameloblastic carcinoma, dentigerous cyst